Interdependent conductances drive infraslow intrinsic rhythmogenesis in a subset of accessory olfactory bulb projection neurons

Monika Gorin, Chryssanthi Tsitoura, Anat Kahan, Katja Watznauer, Daniela R. Drose, Martijn Arts, Rudolf Mathar, Simon O’Connor, Ileana L. Hanganu-Opatz, Yoram Ben-Shaul, Marc Spehr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The accessory olfactory system controls social and sexual behavior. However, key aspects of sensory signaling along the accessory olfactory pathway remain largely unknown. Here, we investigate patterns of spontaneous neuronal activity in mouse accessory olfactory bulb mitral cells, the direct neural link between vomeronasal sensory input and limbic output. Both in vitro and in vivo, we identify a subpopulation of mitral cells that exhibit slow stereotypical rhythmic discharge. In intrinsically rhythmogenic neurons, these periodic activity patterns are maintained in absence of fast synaptic drive. The physiological mechanism underlying mitral cell autorhythmicity involves cyclic activation of three interdependent ionic conductances: subthreshold persistent Na+ current, R-type Ca2+ current, and Ca2+-activated big conductance K+current. Together, the interplay of these distinct conductances triggers infraslow intrinsic oscillations with remarkable periodicity, a default output state likely to affect sensory processing in limbic circuits.

Original languageAmerican English
Pages (from-to)3127-3144
Number of pages18
JournalJournal of Neuroscience
Volume36
Issue number11
DOIs
StatePublished - 16 Mar 2016

Bibliographical note

Publisher Copyright:
© 2016 the authors.

Keywords

  • Intrinsic oscillations
  • Mitral cell
  • Olfactory bulb
  • Pacemaker
  • Rhythmogenesis
  • Vomeronasal system

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