TY - JOUR
T1 - Interethnic differences in drug response
T2 - The contribution of genetic variability in β adrenergic receptor and cytochrome P4502C9
AU - Muszkat, M.
PY - 2007/8
Y1 - 2007/8
N2 - Ethnic differences in drug response have been extensively reported, and ethnicity has been suggested to be useful clinically as a predictor of drug response. Genetic polymorphisms in the genes encoding β1 adrenergic receptor (AR) and β2 AR, targets of β AR antagonists, and in cytochrome P4502C9, the enzyme involved in warfarin metabolism, have the potential to explain some of the observed ethnic variability in drug response and to improve clinical practice.
AB - Ethnic differences in drug response have been extensively reported, and ethnicity has been suggested to be useful clinically as a predictor of drug response. Genetic polymorphisms in the genes encoding β1 adrenergic receptor (AR) and β2 AR, targets of β AR antagonists, and in cytochrome P4502C9, the enzyme involved in warfarin metabolism, have the potential to explain some of the observed ethnic variability in drug response and to improve clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=34447564024&partnerID=8YFLogxK
U2 - 10.1038/sj.clpt.6100142
DO - 10.1038/sj.clpt.6100142
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C2 - 17329986
AN - SCOPUS:34447564024
SN - 0009-9236
VL - 82
SP - 215
EP - 218
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
IS - 2
ER -