Interferon-gamma deficiency attenuates local P. gingivalis-induced Inflammation

Y. Houri-Haddad, W. A. Soskolne, E. Shai, A. Palmon, L. Shapira*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Infection with the periodontal pathogen Porphyromonas gingivalis causes a strong local inflammatory reaction. Using IFNγ-deficient mice, we tested the hypothesis that the absence of IFNγ would result in a reduction of the local pro-inflammatory response to P. gingivalis. Cytokine secretion by macrophages from IFNγ-/- animals was significantly attenuated. Addition of IFNγ restored cytokine secretion. In vivo injection of P. gingivalis into subcutaneous chambers increased the intra-chamber leukocyte counts and TNFα and IL-1β levels. This increase was significantly lower in the IFNγ-/- mice. Local reconstitution of IFNγ-/- mice at the site of inflammation with the IFNγ gene increased the levels of TNFα and decreased the IL-10 levels. Anti-P. gingivalis IgG1 levels, a marker of Th2 response, were higher in immunized IFNγ-/- than in IFNγ+/+ mice. The results suggest that lack of IFNγ reduced the amplitude of the local pro-inflammatory response without decreasing the humoral protective response. The higher IgG1/IgG2a ratio observed supports the possibility of a Th2-dominant response in IFNγ-deficient animals.

Original languageAmerican English
Pages (from-to)395-398
Number of pages4
JournalJournal of Dental Research
Issue number6
StatePublished - 2002
Externally publishedYes


  • Antibody
  • Cytokines
  • Deficiency
  • IFNγ
  • Inflammation
  • Porphyromonas gingivalis


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