Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function

Research output: Chapter in Book/Report/Conference proceedingChapter


Cell function depends on the proper internal organization and regulation of molecules. This chapter will discuss how the family of VICKZ RNA binding proteins are involved in regulating localization, stability, and translation of a set of mRNAs, and, as a result, help control certain cellular functions. The VICKZ proteins represent a paradigm for understanding how the internal design of a cell is intimately related to its physiology. Studying how these proteins function should provide important insights into what happens in cancer and other diseases in which they are aberrantly expressed.
Original languageAmerican English
Title of host publicationOrigin(s) of Design in Nature
Subtitle of host publication A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life
EditorsLiz Swan, Richard Gordon, Joseph Seckbach
Place of PublicationDordrecht
PublisherSpringer Netherlands
Number of pages15
ISBN (Electronic)978-94-007-4156-0
ISBN (Print)978-94-007-4155-3, 978-94-017-7963-0
StatePublished - 2012

Publication series

NameCellular Origin, Life in Extreme Habitats and Astrobiology
ISSN (Print)1566-0400
ISSN (Electronic)2215-0048


  • Neural crest cells
  • CD44 mRNA
  • Nascent Transcript
  • Igf2 mRNA
  • Antisense Morpholino Oligonucleotide


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