Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function

Joel K. Yisraeli

doi:10.1007/978-94-007-4156-0_23

Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function

Joel K. Yisraeli

Department of Developmental Biology and Cancer Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cell function depends on the proper internal organization and regulation of molecules. This chapter will discuss how the family of VICKZ RNA binding proteins are involved in regulating localization, stability, and translation of a set of mRNAs, and, as a result, help control certain cellular functions. The VICKZ proteins represent a paradigm for understanding how the internal design of a cell is intimately related to its physiology. Studying how these proteins function should provide important insights into what happens in cancer and other diseases in which they are aberrantly expressed.

Original language	American English
Title of host publication	Origin(s) of Design in Nature
Subtitle of host publication	A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life
Editors	Liz Swan, Richard Gordon, Joseph Seckbach
Place of Publication	Dordrecht
Publisher	Springer Netherlands
Pages	429-443
Number of pages	15
ISBN (Electronic)	978-94-007-4156-0
ISBN (Print)	978-94-007-4155-3, 978-94-017-7963-0
DOIs	https://doi.org/10.1007/978-94-007-4156-0_23
State	Published - 2012

Publication series

Name	Cellular Origin, Life in Extreme Habitats and Astrobiology
Publisher	Springer
Volume	23
ISSN (Print)	1566-0400
ISSN (Electronic)	2215-0048

Keywords

Neural crest cells
CD44 mRNA
Nascent Transcript
Igf2 mRNA
Antisense Morpholino Oligonucleotide

Access to Document

10.1007/978-94-007-4156-0_23

Cite this

Yisraeli, J. K. (2012). Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function. In L. Swan, R. Gordon, & J. Seckbach (Eds.), Origin(s) of Design in Nature: A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life (pp. 429-443). (Cellular Origin, Life in Extreme Habitats and Astrobiology; Vol. 23). Springer Netherlands. https://doi.org/10.1007/978-94-007-4156-0_23

Yisraeli, Joel K. / Interior Cell Design : VICKZ Proteins Mediate RNA Localization and Cell Function. Origin(s) of Design in Nature: A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life. editor / Liz Swan ; Richard Gordon ; Joseph Seckbach. Dordrecht : Springer Netherlands, 2012. pp. 429-443 (Cellular Origin, Life in Extreme Habitats and Astrobiology).

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abstract = "Cell function depends on the proper internal organization and regulation of molecules. This chapter will discuss how the family of VICKZ RNA binding proteins are involved in regulating localization, stability, and translation of a set of mRNAs, and, as a result, help control certain cellular functions. The VICKZ proteins represent a paradigm for understanding how the internal design of a cell is intimately related to its physiology. Studying how these proteins function should provide important insights into what happens in cancer and other diseases in which they are aberrantly expressed.",

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Yisraeli, JK 2012, Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function. in L Swan, R Gordon & J Seckbach (eds), Origin(s) of Design in Nature: A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol. 23, Springer Netherlands, Dordrecht, pp. 429-443. https://doi.org/10.1007/978-94-007-4156-0_23

Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function. / Yisraeli, Joel K.
Origin(s) of Design in Nature: A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life. ed. / Liz Swan; Richard Gordon; Joseph Seckbach. Dordrecht: Springer Netherlands, 2012. p. 429-443 (Cellular Origin, Life in Extreme Habitats and Astrobiology; Vol. 23).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AB - Cell function depends on the proper internal organization and regulation of molecules. This chapter will discuss how the family of VICKZ RNA binding proteins are involved in regulating localization, stability, and translation of a set of mRNAs, and, as a result, help control certain cellular functions. The VICKZ proteins represent a paradigm for understanding how the internal design of a cell is intimately related to its physiology. Studying how these proteins function should provide important insights into what happens in cancer and other diseases in which they are aberrantly expressed.

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KW - CD44 mRNA

KW - Nascent Transcript

KW - Igf2 mRNA

KW - Antisense Morpholino Oligonucleotide

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DO - 10.1007/978-94-007-4156-0_23

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T3 - Cellular Origin, Life in Extreme Habitats and Astrobiology

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Yisraeli JK. Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function. In Swan L, Gordon R, Seckbach J, editors, Origin(s) of Design in Nature: A Fresh, Interdisciplinary Look at How Design Emerges in Complex Systems, Especially Life. Dordrecht: Springer Netherlands. 2012. p. 429-443. (Cellular Origin, Life in Extreme Habitats and Astrobiology). doi: 10.1007/978-94-007-4156-0_23

Interior Cell Design: VICKZ Proteins Mediate RNA Localization and Cell Function

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