TY - JOUR
T1 - Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice
AU - Abdul-Hai, A.
AU - Ben-Yehuda, A.
AU - Weiss, L.
AU - Friedman, G.
AU - Zakay-Rones, Z.
AU - Slavin, S.
AU - Or, R.
PY - 1997/3/2
Y1 - 1997/3/2
N2 - Lethally irradiated BALB/c mice were reconstituted by syngeneic bone marrow transplantation (BMT), and injected with recombinant interleukin 7 (rIL-7), recombinant interleukin 2 (rIL-2), or saline 10 days post-transplantation. Intranasal infection with A/PR8/34 influenza virus 2 weeks after BMT was associated with the highest survival rate in the rIL-7-treated group. The protective mechanism elicited by rLL-7, as manifested by very low virus titers in the lung, involves T and B cell functions. High hemagglutinin inhibition antibody levels were observed on days 7 and 12 post-challenge in the rIL-7 mice. Moreover, the anti-influenza cytotoxic T lymphocyte activity was induced primarily by rIL-7, leaving the effect of rIL-2 on the same level as that of the control. Thus, rIL-7 promotes both T cell-mediated function and B cell production during the immunodeficient state after BMT. This cytokine may prove a potential immunotherapeutic modality in BMT recipients.
AB - Lethally irradiated BALB/c mice were reconstituted by syngeneic bone marrow transplantation (BMT), and injected with recombinant interleukin 7 (rIL-7), recombinant interleukin 2 (rIL-2), or saline 10 days post-transplantation. Intranasal infection with A/PR8/34 influenza virus 2 weeks after BMT was associated with the highest survival rate in the rIL-7-treated group. The protective mechanism elicited by rLL-7, as manifested by very low virus titers in the lung, involves T and B cell functions. High hemagglutinin inhibition antibody levels were observed on days 7 and 12 post-challenge in the rIL-7 mice. Moreover, the anti-influenza cytotoxic T lymphocyte activity was induced primarily by rIL-7, leaving the effect of rIL-2 on the same level as that of the control. Thus, rIL-7 promotes both T cell-mediated function and B cell production during the immunodeficient state after BMT. This cytokine may prove a potential immunotherapeutic modality in BMT recipients.
KW - Bone marrow transplantation
KW - Interleukin 7
KW - T lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=0030894382&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1700706
DO - 10.1038/sj.bmt.1700706
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C2 - 9085732
AN - SCOPUS:0030894382
SN - 0268-3369
VL - 19
SP - 539
EP - 543
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 6
ER -
