TY - JOUR
T1 - International Central Nervous System and Ocular Lymphoma Workshop
T2 - Recommendations for the future
AU - Nussenblatt, Robert
AU - Chan, Chi Chao
AU - Wilson, Wyndham
AU - Hochman, Jacob
AU - Gottesman, Michael
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Purpose: To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL). Methods: NIH campus workshop discussion focusing on future work in both clinical and basic lymphoma research. Results: The discussion lead to recommendations on elucidating disease pathobiology, improving diagnostic accuracy and sensitivity, and novel therapeutic strategies. Conclusions: Approaches which have been successfully applied to other neoplasms, such as microarray, may be applied to improve diagnostic accuracy and sensitivity of PCNSL and PIOL and should be systematically incorporated into clinical trials of both. Development of animal models of PCNSL and PIOL may be useful in understanding the unique ocular and CNS milieu. Disease detection by radiological, nuclear medicine, molecular and flow cytometric approaches should be systematically studied to improve early diagnosis, accurate staging, and response evaluation. Improved therapy remains the ultimate goal. Efforts in these arenas should be coordinated on a national and international level.
AB - Purpose: To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL). Methods: NIH campus workshop discussion focusing on future work in both clinical and basic lymphoma research. Results: The discussion lead to recommendations on elucidating disease pathobiology, improving diagnostic accuracy and sensitivity, and novel therapeutic strategies. Conclusions: Approaches which have been successfully applied to other neoplasms, such as microarray, may be applied to improve diagnostic accuracy and sensitivity of PCNSL and PIOL and should be systematically incorporated into clinical trials of both. Development of animal models of PCNSL and PIOL may be useful in understanding the unique ocular and CNS milieu. Disease detection by radiological, nuclear medicine, molecular and flow cytometric approaches should be systematically studied to improve early diagnosis, accurate staging, and response evaluation. Improved therapy remains the ultimate goal. Efforts in these arenas should be coordinated on a national and international level.
KW - Imaging
KW - Intraocular lymphoma
KW - Masquerade syndrome
KW - Microarray
UR - http://www.scopus.com/inward/record.url?scp=33745144968&partnerID=8YFLogxK
U2 - 10.1080/09273940600630170
DO - 10.1080/09273940600630170
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C2 - 16827214
AN - SCOPUS:33745144968
SN - 0927-3948
VL - 14
SP - 139
EP - 144
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 3
ER -