Interplay among subunit identity, subunit proportion, chain length, and stereochemistry in the activity profile of sequence-random peptide mixtures

Zvi Hayouka, Saswata Chakraborty, Runhui Liu, Melissa D. Boersma, Bernard Weisblum, Samuel H. Gellman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Fmoc-based solid-phase synthesis methodology was used to prepare peptide mixtures containing one type of hydrophobic residue and one type of cationic residue. Each mixture was random in terms of sequence but highly controlled in terms of length. Analysis of the antibacterial and hemolytic properties of these mixtures revealed that selective antibacterial activity can be achieved with heterochiral binary mixtures but not homochiral binary mixture, if the proper amino acid residues are used.

Original languageAmerican English
Pages (from-to)11748-11751
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number32
DOIs
StatePublished - 14 Aug 2013
Externally publishedYes

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