TY - JOUR
T1 - Interplay between population firing stability and single neuron dynamics in hippocampal networks
AU - Slomowitz, Edden
AU - Styr, Boaz
AU - Vertkin, Irena
AU - Milshtein-Parush, Hila
AU - Nelken, Israel
AU - Slutsky, Michael
AU - Slutsky, Inna
N1 - Publisher Copyright:
© 2015, eLife Sciences Publications Ltd. All rights reserved.
PY - 2015/1/2
Y1 - 2015/1/2
N2 - Neuronal circuits' ability to maintain the delicate balance between stability and flexibility in changing environments is critical for normal neuronal functioning. However, to what extent individual neurons and neuronal populations maintain internal firing properties remains largely unknown. Here, we show that distributions of spontaneous population firing rates and synchrony are subject to accurate homeostatic control following increase of synaptic inhibition in cultured hippocampal networks. Reduction in firing rate riggered synaptic and intrinsic adaptive responses operating as global homeostatic mechanisms to maintain firing macro-stability, without achieving local homeostasis at the single-neuron level. Adaptive mechanisms, while stabilizing population firing properties, reduced short-term facilitation essential for synaptic discrimination of input patterns. Thus, invariant ongoing population dynamics emerge from intrinsically unstable activity patterns of individual neurons and synapses. The observed differences in the precision of homeostatic control at different spatial scales challenge cell-autonomous theory of network homeostasis and suggest existence of network-wide regulation rules.
AB - Neuronal circuits' ability to maintain the delicate balance between stability and flexibility in changing environments is critical for normal neuronal functioning. However, to what extent individual neurons and neuronal populations maintain internal firing properties remains largely unknown. Here, we show that distributions of spontaneous population firing rates and synchrony are subject to accurate homeostatic control following increase of synaptic inhibition in cultured hippocampal networks. Reduction in firing rate riggered synaptic and intrinsic adaptive responses operating as global homeostatic mechanisms to maintain firing macro-stability, without achieving local homeostasis at the single-neuron level. Adaptive mechanisms, while stabilizing population firing properties, reduced short-term facilitation essential for synaptic discrimination of input patterns. Thus, invariant ongoing population dynamics emerge from intrinsically unstable activity patterns of individual neurons and synapses. The observed differences in the precision of homeostatic control at different spatial scales challenge cell-autonomous theory of network homeostasis and suggest existence of network-wide regulation rules.
UR - http://www.scopus.com/inward/record.url?scp=85005893717&partnerID=8YFLogxK
U2 - 10.7554/eLife.04378
DO - 10.7554/eLife.04378
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C2 - 25556699
AN - SCOPUS:85005893717
SN - 2050-084X
VL - 2015
JO - eLife
JF - eLife
IS - 4
M1 - e04378
ER -