Abstract
Aims: The objective of the study is to determine the demographics and the in-hospital outcome of diabetic and non-diabetic patients treated with percutaneous coronary interventions (PCI) in Europe, to report the type of equipment and technology used for PCI procedures in diabetics and to clarify whether the treatment of diabetic patients complies with current European Society of Cardiology (ESC) guidelines. Methods and results: A total of 14,458 patients treated with PCI were enrolled from 29 member countries of the ESC between June 2005 and January 2006. Data were collected on patient characteristics and treatment, using new Cardiology Audit and Registration Data standards. In total, 3,603 patients (24.9%) were diabetic. Diabetics were older, more often female and had a higher body mass index than non-diabetics. Diabetics had higher rates of hypercholesterolaemia and hypertension, while current smokers were more frequent in the non-diabetics. Diabetics also had significantly higher rates of previous cardiovascular events. Clopidogrel was administered only in 48.1% of diabetic patients before PCI, while IIb/IIIa inhibitors were 22.9% during PCI. At discharge, there was a major adjustment of treatment with increases in the use of Beta-blocker (80.4%), angiotensin converting enzyme inhibitor (ACEI, 71.3%) and statins (89.8%) compared with on admission (Beta-blocker 60.9%, ACEI 55.0%, statin 63.1%). Inhospital mortality was higher in diabetics (1.8% vs 1.2%) although the in-hospital MACCE rate was not significantly different (3.6% vs 3.0%, p=0.09). Conclusions: Diabetic patients treated with PCI were older with more comorbidity. According to ESC guideline, the under-usage of clopidogrel, GP IIb/IIIa inhibitors should be improved. PCI is now taken as a good opportunity to adjust the use of appropriate medication.
| Original language | English |
|---|---|
| Pages (from-to) | 578-587 |
| Number of pages | 10 |
| Journal | EuroIntervention |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 Mar 2009 |
Keywords
- Angioplasty
- Diabetics
- Drug eluting stent
- European Heart Survey
- Risk factors
Access to Document
Other files and links
Fingerprint
Dive into the research topics of 'Interventional treatment in diabetics in the era of drugeluting stents and compliance to the ESC guidelines: Lessons learned from the Euro Heart Survey Programme'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: EuroIntervention, Vol. 4, No. 5, 01.03.2009, p. 578-587.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Interventional treatment in diabetics in the era of drugeluting stents and compliance to the ESC guidelines
T2 - Lessons learned from the Euro Heart Survey Programme
AU - Onuma, Yoshinobu
AU - Kukreja, Neville
AU - Ramcharitar, Steve
AU - Hochadel, Matthias
AU - Gitt, Anselm
AU - Serruys, Patrick
AU - Marco, Jean
AU - Vahanian, Alec
AU - Weidinger, Franz
AU - Wijns, William
AU - Zeymer, Uwe
AU - Silber, Sigmund
AU - Seabra-Gomez, Ricardo
AU - Eberli, Franz
AU - Manini, Malika
AU - Bramley, Claire
AU - Laforest, Valerie
AU - Taylor, Charles
AU - Huber, Kurt
AU - Backer, Guy De
AU - Sirakova, Vera
AU - Cerbak, Roman
AU - Thayssen, Per
AU - Aziz, Osama Abdel
AU - Tammam, Khalid
AU - Lehto, Seppo
AU - Delahaye, François
AU - Kobulia, Bondo
AU - Zeymer, Uwe
AU - Cokkinos, Dennis
AU - Kremastinos, Dimitrios
AU - Karlocai, Kristof
AU - Shelley, Emer
AU - Behar, Shlomo
AU - Maggioni, Aldo
AU - Grabauskiene, Virginija
AU - Deckers, Jaap
AU - Asmussen, Inger
AU - Stepinska, Janina
AU - Gonçalves, Lino
AU - Fonseca, Candida
AU - Mareev, Vyacheslav
AU - Vasilijevic, Zorana
AU - Riecansky, Montenegro Igor
AU - Kenda, Miran F.
AU - Lopez-Sendon, Jose Luis
AU - Rosengren, Annika
AU - Buser, Peter
AU - Okay, Tugrul
AU - Sychov, Oleg
AU - Schofield, Peter
AU - Gitt, A. K.
AU - Tavazzi, L.
AU - Gomes, R. Seabra
AU - de la Iglesia, J. Marrugat
AU - Wallentin, L.
AU - Kearney, P.
AU - McGregor, K.
AU - Simoons, M. L.
AU - Squibb, Bristol Myers
AU - Lilly, Eli
AU - Margaryan, Kristine
AU - Khachatryan, Shahen
AU - Weidinger, Franz
AU - Doerler, Jakob
AU - Stocker, Eva Maria
AU - Altenberger, Innsbruck Johann
AU - Heigert, Matthias
AU - Pichler, Max
AU - Christ, Salzburg Gunther
AU - Glogar, Helmut
AU - Lang, Irene
AU - Ingerle, Stefan
AU - De Wilde, Philip
AU - de Marneffe, Michel
AU - Vrolix, Bruxelles M.
AU - Dens, Joseph
AU - Lierde, Johan Van
AU - De Wagter, Genk X.
AU - Carlier, Gent Marc
AU - Weyne, Gilly Antoon
AU - Legrand, Kortrijk Victor
AU - Doneux, Pierre
AU - Gach, Olivier
AU - Davin, Laurent
AU - Mievis, Liège Eric
AU - Massart, Pierre Emmanuel
AU - Holvoet, Namur G.
AU - Giunio, Lovel
AU - Glavas, Duska
AU - Vukovic, Ivica
AU - Markovic, Branimir
AU - Duplancic, Darko
AU - Runjic, F.
AU - Galic, Spilt Edvard
AU - Mirat, Jure
AU - Kala, Petr
AU - Semenka, Jiri
AU - Hlinomaz, Ota
AU - Petrikovits, Erik
AU - Widimsky, Brno Petr
AU - Tousek, Petr
AU - Varvarovsky, Prague Ivo
AU - Thayssen, P.
AU - Cappelen, Helle
AU - Helqvist, Odense Steffen
AU - Kelbaek, Henning
AU - Jorgensen, Erik
AU - Engstrom, T.
AU - Saunamaki, Kari
AU - Kastrup, Jens
AU - Clemmensen, Peter
AU - Hansen, H.
AU - Al Abbadi, Magid
AU - Tammam, Khalid
AU - Razek, Hany Abdel
AU - Aboul el Nasr, Gamal
AU - Ragi, Hany
AU - Ibrihim, Basam
AU - Zarif, Basam
AU - el Banhawy, Naha
AU - Sorour, Khalid
AU - Meguid, Mohamed Abdel
AU - Mahrous, Ahmed
AU - Al Khashab, Khalid Ahmed
AU - Ahmed Abd Elmoniem, Fayoum
AU - El Emry, Metwaly
AU - El Naggar, Amr
AU - Saad, Benha Aly
AU - Laanmets, Peep
AU - Voitk, Jyri
AU - Lutter, Piia
AU - Jarvekulg, Sigrid
AU - Jalakas, Mati
AU - Reinmets, Julia
AU - Marandi, Toomas
AU - Peeba, Margus
AU - Serka, Tarmo
AU - Syvannne, Mikko
AU - Kaihovirta, Esa
AU - Korpilahti, Helsinki Kari
AU - Vaittinen, Mari Anne
AU - Bassand, Jean Pierre
AU - Espinosa, Denis Pales
AU - Cottin, Besancon Yves
AU - Lhuillier, Isabelle
AU - Buffet, Philippe
AU - Lorgis, L.
AU - Machecourt, Dijon Jacques
AU - Bertrand, Bernard
AU - Serrano, Delphine
AU - Bonnet, Grenoble Jean Louis
AU - Steg, Marseille Philippe Gabriel
AU - Juliard, Jean Michel
AU - Farnoud, Reza
AU - Delarche, Paris Nicolas
AU - Marco, Pau Jean
AU - Petit, Frederic
AU - Farah, Bruno
AU - Carrie, Didier
AU - Galinier, Michel
AU - Puel, Jacques
AU - Cahuzac, Jacqueline
AU - Roncalli, Jerome
AU - Tauzin, Stephane
AU - Elbaz, Meyer
AU - Schachinger, Volker
AU - Gitt, Frankfurt Anselm
AU - Zeymer, Uwe
AU - am Rhein Ralf Zahn, Ludwigshafen
AU - Fraiture, Boris
AU - Haetinger, Siegberto
AU - Klepzig, Nurnberg H.
AU - Girth, E.
AU - Hauber, A.
AU - Firschke, Offenbach Christian
AU - Widmaier, Jochen
AU - Hofbauer, Florian
AU - Huttl, Stefan
AU - Sechtem, Pfaffenhofen Udo
AU - Parade, Ulli
AU - Linnartz, Stuttgart Georg
AU - Cokkinos, D.
AU - Andrianidis, Stalikas
AU - Tsiavou, Natassa
AU - Papaioannou, Georgios
AU - Deliargyris, Efthymios
AU - Attikis, Maroussi
AU - Alexopoulos, Dimitrios
AU - Davlouros, Periklis
AU - Tsikaderis, Dimitrios
AU - Dardas, Petros
AU - Mezilis, Nikolaos
AU - Istvan, Edes
AU - Zoltan, Bakos
AU - Turgeman, Yoav
AU - Khaled, Suleiman
AU - Feldman, Alexander
AU - Jafari, Jamal
AU - Manevich, Iliya
AU - Cafri, Carlos
AU - Ilia, Reuben
AU - Abu-Ful, Akram
AU - Yaroslavslev, Sergei
AU - Wainstain, Jean Mark
AU - Rosenchtein, Gabriel
AU - Sheva, Beer
AU - Krakover, Ricardo
AU - Yakov, Beer
AU - Halon, David
AU - Gruberg, Luis
AU - Markiewicz, Walter
AU - Grenadier, Ehud
AU - Boulos, Monther
AU - Roguin, Ariel
AU - Kerner, Arthur
AU - Amikam, Shlomo
AU - Ben-Tzvi, Margalit
AU - Rezmovitz, Jeremy
AU - Mosseri, Haifa Morris
AU - Lotan, Haim
AU - Varshizky, Boris
AU - Nassar, Hisham
AU - Daninberg, Haim
AU - Rot, David
AU - Vais, Tedi
AU - Benhorin, Jesaia
AU - Keren, Andre
AU - Medina, Aharon
AU - Huri, Zahi
AU - Brandis, Jerusalem Simcha
AU - Schoenmann, Guy
AU - Kornowski, Netanya Ran
AU - Assali, Abed
AU - Fuch, Shmuel
AU - Hasdai, David
AU - Brosh, David
AU - Sela, Offer
AU - Teplitski, Igal
AU - Tikva, Petach
AU - Eisenberg, Oded
AU - Banai, Shmuel
AU - Finkelstein, Ariel
AU - Hasin, Yonathan
AU - Aboud, Muein
AU - Nahir, Menachem
AU - Qarwani, Daud
AU - Diab, Genem
AU - Meloni, Luigi
AU - Lai, Giorgio
AU - Cadeddu, M.
AU - Pirisi, R.
AU - Bonechi, Francesco
AU - Nassi, Franco
AU - Nieri, Massimiliano
AU - Taiti, Andrea
AU - Naldoni, Alessandra
AU - Calabro, Francesco
AU - Achilli, Felice
AU - Maggiolini, Stefano
AU - Piatti, Luigi
AU - Tiberti, Gianluca
AU - Addamiano, Piero
AU - Berti, Sergio
AU - Ravani, Marcello
AU - Palmieri, Cataldo
AU - Trianni, Giuseppe
AU - Cardullo, Simona
AU - Cioppa, Angelo
AU - Rubino, Paolo
AU - Ambrosini, Vittorio
AU - Salemme, L.
AU - Sorropago, G.
AU - Tesorio, T.
AU - Geraci, Giuseppe
AU - Scalise, Filippo
AU - Mazzeti, Simone
AU - Auguadro, Carla
AU - Esposito, Giovanni
AU - Canali, Guido
AU - Caccia, Maria Enrica
AU - Ruggieri, Chiara
AU - Benedetta, Bertola
AU - de Cesare, Nicoletta
AU - De Benedictis, M.
AU - Coco, Tiziana
AU - Manzotti, Sabrina
AU - Fraz, Osio Sotto
AU - Marraccini, Paolo
AU - Danesi, Alessandro
AU - Ricci, R.
AU - Ferraironi, A.
AU - Olivieri, E.
AU - Chiera, A.
AU - Garducci, Stefano
AU - Grasseli, Daniela
AU - Kearney, Peter
AU - McFadden, Eugene
AU - Cahill, Noel
AU - Quinn, Martin
AU - Crean, Peter
AU - Caroll, Eileen
AU - Foley, David
AU - O'Connor, Stephen
AU - O'Hanlon, Rory
AU - Lynch, Bernadette
AU - O'Donnell, Srah
AU - Roy, James
AU - O'Brien, Darragh
AU - Krastina, Asnate
AU - Erglis, Andrejs
AU - Lawand, Samih
AU - Dorniak, Waldemar
AU - Klaudel, Jacek
AU - Pawlowski, Krzysztof
AU - Trenkner, Wojciech
AU - Janion, Marianna
AU - Sadowski, Marcin
AU - Janion-Sadowska, Agnieszka
AU - Skorupa, Izabella
AU - Bystryk, Leszek
AU - Kern, Adam
AU - Janiak, Bartlomiej
AU - Szelemej, Roman
AU - Ruzyllo, Witold
AU - Witkowski, Adam
AU - Deptuch, Tomasz
AU - Maczynska-Mazuruk, Renata
AU - Budaj, Andrezj
AU - Cegieska, Kokowicz Lewandowski
AU - Opolski, Grzegorz
AU - Wilczyska, Joanna
AU - Roik, Marek
AU - Kochman, Janusz
AU - Martins, Dinis
AU - Goncalves, Isabel Maria Fernandes Joao
AU - Pereira, Helder
AU - Faria, Henrique
AU - Calisto, Joao
AU - Goncalves, Lino
AU - Matos, Victor
AU - Leitao-Marques, Antonio
AU - Costa, M.
AU - Oliveira, H.
AU - Mota, P.
AU - Santos, Walter
AU - Brandao, Victor
AU - Caires, Faro Graca
AU - Silva, Bruno
AU - Teles, Funchal Rui Campante
AU - Almeida, Manuel
AU - Goncalves, Pedro
AU - Raposo, Luis
AU - Mourao, Luis
AU - Bernardes, Luis
AU - Pedro, Paulo G.
AU - Ferreira, Rui
AU - Conduto, Rui
AU - Quininha, Jorge
AU - Patricio, Lino
AU - Cacela, Duarte
AU - Goncalves, Jose Maria
AU - de Sousa, Lidia
AU - Adao, Manuela
AU - Carvalho, Lisbon Henrique Cyrne
AU - Romeira, Helia
AU - Sousa, Jose Paulino
AU - Garcia, Jose Manuel Mota
AU - Silva, J. Carlos
AU - Magalhaes, Domingos
AU - Santos, Porto Ricardo
AU - Mendes, Setubal Pedro Gama
AU - Pipa, Joao
AU - Nunes, Luis
AU - Ferreira, Pedro
AU - Vinereanu, Dragos
AU - Udroiu, Cristian
AU - Florescu, Nicolae
AU - Parvu, Octavian
AU - Stoicescu, Claudiu
AU - Dorobantu, Maria
AU - Balanescu, Serban Mihai
AU - Niculescu, Rodica
AU - Calmac, Lucian
AU - Marinescu, M.
AU - Olinic, Bucharest Dan
AU - Ober, Mihai
AU - Homorodean, Calin
AU - Budurea, Claudia
AU - Hij, Adrian
AU - Anton, Florin
AU - Cluj-Napoca,
AU - Ortan, Florin
AU - Suciu, Ciprian
AU - Ursu, Mihai
AU - Baba, Costica
AU - Targu-Mures,
AU - Dragulescu, Stefan Iosif
AU - Petrescu, Lucian
AU - Slovenski, Milovan
AU - Gavrilescu, Dan
AU - Dina, Cristian
AU - Mut, Bogdan
AU - Babic, Rade
AU - Colic, Mirko
AU - Topic, Dragan
AU - Vilarrasa, Joan Bassaganyas
AU - Pont, Marti Puigfel
AU - Martorell, Rafael Masia
AU - Rohlfs, Izabella
AU - Moreno, Rafael Melgares
AU - Irurita, Maria
AU - Irurita, Juncal
AU - de Gran Canaria, Las Palmas
AU - Cervantes, Carlos Escobar
AU - Galvan, Teresa
AU - Navarro, Jimenez
AU - Franco, Dominguez
AU - Rodriguez, Ignacio Santos
AU - Ramirez, Victor Hogo
AU - Fernandes-Aviles, Francisco
AU - Revilla, Ana
AU - Mota, Pedro
AU - Masson, Nicholas
AU - Dupertuis, Virginie
AU - Kachboura, Salem
AU - Iyisoy, Atila
AU - Erol, Mustafa Kemal
AU - Ongen, Zeki
AU - Babalik, Erhan
AU - Oskan, Mehmet
AU - Ozdemir, Nihal
AU - Oto, Ali
AU - Aytemir, Kudret
AU - Yavuz, Bunyemin
AU - Sahin, Mahmut
AU - Durna, Kenan
AU - Aytekin, Vedat
AU - Demiroglu, Cemsit
AU - Gulbaran, Murat
AU - Aytekin, Saide
AU - Catakoglu, Alp Burak
AU - Ozme, Burak
AU - Gemici, Gokmen
AU - Feray, Hasan
AU - Schofield, P. M.
AU - Kahn, S.
AU - Clarke, S.
AU - Millington, Heather
AU - Di Mario, Carlo
AU - Dempster, Debra
AU - Henderson, Robert Anthony
AU - Burton, Jane
AU - Falcon-Lang, Della
PY - 2009/3/1
Y1 - 2009/3/1
N2 - Aims: The objective of the study is to determine the demographics and the in-hospital outcome of diabetic and non-diabetic patients treated with percutaneous coronary interventions (PCI) in Europe, to report the type of equipment and technology used for PCI procedures in diabetics and to clarify whether the treatment of diabetic patients complies with current European Society of Cardiology (ESC) guidelines. Methods and results: A total of 14,458 patients treated with PCI were enrolled from 29 member countries of the ESC between June 2005 and January 2006. Data were collected on patient characteristics and treatment, using new Cardiology Audit and Registration Data standards. In total, 3,603 patients (24.9%) were diabetic. Diabetics were older, more often female and had a higher body mass index than non-diabetics. Diabetics had higher rates of hypercholesterolaemia and hypertension, while current smokers were more frequent in the non-diabetics. Diabetics also had significantly higher rates of previous cardiovascular events. Clopidogrel was administered only in 48.1% of diabetic patients before PCI, while IIb/IIIa inhibitors were 22.9% during PCI. At discharge, there was a major adjustment of treatment with increases in the use of Beta-blocker (80.4%), angiotensin converting enzyme inhibitor (ACEI, 71.3%) and statins (89.8%) compared with on admission (Beta-blocker 60.9%, ACEI 55.0%, statin 63.1%). Inhospital mortality was higher in diabetics (1.8% vs 1.2%) although the in-hospital MACCE rate was not significantly different (3.6% vs 3.0%, p=0.09). Conclusions: Diabetic patients treated with PCI were older with more comorbidity. According to ESC guideline, the under-usage of clopidogrel, GP IIb/IIIa inhibitors should be improved. PCI is now taken as a good opportunity to adjust the use of appropriate medication.
AB - Aims: The objective of the study is to determine the demographics and the in-hospital outcome of diabetic and non-diabetic patients treated with percutaneous coronary interventions (PCI) in Europe, to report the type of equipment and technology used for PCI procedures in diabetics and to clarify whether the treatment of diabetic patients complies with current European Society of Cardiology (ESC) guidelines. Methods and results: A total of 14,458 patients treated with PCI were enrolled from 29 member countries of the ESC between June 2005 and January 2006. Data were collected on patient characteristics and treatment, using new Cardiology Audit and Registration Data standards. In total, 3,603 patients (24.9%) were diabetic. Diabetics were older, more often female and had a higher body mass index than non-diabetics. Diabetics had higher rates of hypercholesterolaemia and hypertension, while current smokers were more frequent in the non-diabetics. Diabetics also had significantly higher rates of previous cardiovascular events. Clopidogrel was administered only in 48.1% of diabetic patients before PCI, while IIb/IIIa inhibitors were 22.9% during PCI. At discharge, there was a major adjustment of treatment with increases in the use of Beta-blocker (80.4%), angiotensin converting enzyme inhibitor (ACEI, 71.3%) and statins (89.8%) compared with on admission (Beta-blocker 60.9%, ACEI 55.0%, statin 63.1%). Inhospital mortality was higher in diabetics (1.8% vs 1.2%) although the in-hospital MACCE rate was not significantly different (3.6% vs 3.0%, p=0.09). Conclusions: Diabetic patients treated with PCI were older with more comorbidity. According to ESC guideline, the under-usage of clopidogrel, GP IIb/IIIa inhibitors should be improved. PCI is now taken as a good opportunity to adjust the use of appropriate medication.
KW - Angioplasty
KW - Diabetics
KW - Drug eluting stent
KW - European Heart Survey
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=65549110323&partnerID=8YFLogxK
U2 - 10.4244/EIJV4I5A98
DO - 10.4244/EIJV4I5A98
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 19378677
AN - SCOPUS:65549110323
SN - 1774-024X
VL - 4
SP - 578
EP - 587
JO - EuroIntervention
JF - EuroIntervention
IS - 5
ER -