Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie, Moshe Biton, Jose Ordovas-Montanes, Keri M. Sullivan, Grace Burgin, Daniel B. Graham, Rebecca H. Herbst, Noga Rogel, Michal Slyper, Julia Waldman, Malika Sud, Elizabeth Andrews, Gabriella Velonias, Adam L. Haber, Karthik Jagadeesh, Sanja Vickovic, Junmei Yao, Christine Stevens, Danielle Dionne, Lan T. NguyenAlexandra Chloé Villani, Matan Hofree, Elizabeth A. Creasey, Hailiang Huang, Orit Rozenblatt-Rosen, John J. Garber, Hamed Khalili, A. Nicole Desch, Mark J. Daly, Ashwin N. Ananthakrishnan*, Alex K. Shalek, Ramnik J. Xavier, Aviv Regev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

610 Scopus citations

Abstract

Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

Original languageAmerican English
Pages (from-to)714-730.e22
JournalCell
Volume178
Issue number3
DOIs
StatePublished - 25 Jul 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • anti-TNF resistance
  • cell-cell interactions
  • colon
  • genome-wide association studies
  • inflammation
  • inflammatory bowel disease
  • large intestine
  • single-cell RNA-seq
  • single-cell genomics
  • ulcerative colitis

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