Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie; Moshe Biton; Jose Ordovas-Montanes; Keri M. Sullivan; Grace Burgin; Daniel B. Graham; Rebecca H. Herbst; Noga Rogel; Michal Slyper; Julia Waldman; Malika Sud; Elizabeth Andrews; Gabriella Velonias; Adam L. Haber; Karthik Jagadeesh; Sanja Vickovic; Junmei Yao; Christine Stevens; Danielle Dionne; Lan T. Nguyen; Alexandra Chloé Villani; Matan Hofree; Elizabeth A. Creasey; Hailiang Huang; Orit Rozenblatt-Rosen; John J. Garber; Hamed Khalili; A. Nicole Desch; Mark J. Daly; Ashwin N. Ananthakrishnan; Alex K. Shalek; Ramnik J. Xavier; Aviv Regev

doi:10.1016/j.cell.2019.06.029

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie, Moshe Biton, Jose Ordovas-Montanes, Keri M. Sullivan, Grace Burgin, Daniel B. Graham, Rebecca H. Herbst, Noga Rogel, Michal Slyper, Julia Waldman, Malika Sud, Elizabeth Andrews, Gabriella Velonias, Adam L. Haber, Karthik Jagadeesh, Sanja Vickovic, Junmei Yao, Christine Stevens, Danielle Dionne, Lan T. NguyenAlexandra Chloé Villani, Matan Hofree, Elizabeth A. Creasey, Hailiang Huang, Orit Rozenblatt-Rosen, John J. Garber, Hamed Khalili, A. Nicole Desch, Mark J. Daly, Ashwin N. Ananthakrishnan^*, Alex K. Shalek, Ramnik J. Xavier, Aviv Regev

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

684 Scopus citations

Abstract

Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

Original language	English
Pages (from-to)	714-730.e22
Journal	Cell
Volume	178
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.06.029
State	Published - 25 Jul 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

anti-TNF resistance
cell-cell interactions
colon
genome-wide association studies
inflammation
inflammatory bowel disease
large intestine
single-cell RNA-seq
single-cell genomics
ulcerative colitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2019.06.029

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Smillie, C. S., Biton, M., Ordovas-Montanes, J., Sullivan, K. M., Burgin, G., Graham, D. B., Herbst, R. H., Rogel, N., Slyper, M., Waldman, J., Sud, M., Andrews, E., Velonias, G., Haber, A. L., Jagadeesh, K., Vickovic, S., Yao, J., Stevens, C., Dionne, D., ... Regev, A. (2019). Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell, 178(3), 714-730.e22. https://doi.org/10.1016/j.cell.2019.06.029

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title = "Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis",

abstract = "Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.",

keywords = "anti-TNF resistance, cell-cell interactions, colon, genome-wide association studies, inflammation, inflammatory bowel disease, large intestine, single-cell RNA-seq, single-cell genomics, ulcerative colitis",

author = "Smillie, {Christopher S.} and Moshe Biton and Jose Ordovas-Montanes and Sullivan, {Keri M.} and Grace Burgin and Graham, {Daniel B.} and Herbst, {Rebecca H.} and Noga Rogel and Michal Slyper and Julia Waldman and Malika Sud and Elizabeth Andrews and Gabriella Velonias and Haber, {Adam L.} and Karthik Jagadeesh and Sanja Vickovic and Junmei Yao and Christine Stevens and Danielle Dionne and Nguyen, {Lan T.} and Villani, {Alexandra Chlo{\'e}} and Matan Hofree and Creasey, {Elizabeth A.} and Hailiang Huang and Orit Rozenblatt-Rosen and Garber, {John J.} and Hamed Khalili and Desch, {A. Nicole} and Daly, {Mark J.} and Ananthakrishnan, {Ashwin N.} and Shalek, {Alex K.} and Xavier, {Ramnik J.} and Aviv Regev",

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doi = "10.1016/j.cell.2019.06.029",

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Smillie, CS, Biton, M, Ordovas-Montanes, J, Sullivan, KM, Burgin, G, Graham, DB, Herbst, RH, Rogel, N, Slyper, M, Waldman, J, Sud, M, Andrews, E, Velonias, G, Haber, AL, Jagadeesh, K, Vickovic, S, Yao, J, Stevens, C, Dionne, D, Nguyen, LT, Villani, AC, Hofree, M, Creasey, EA, Huang, H, Rozenblatt-Rosen, O, Garber, JJ, Khalili, H, Desch, AN, Daly, MJ, Ananthakrishnan, AN, Shalek, AK, Xavier, RJ & Regev, A 2019, 'Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis', Cell, vol. 178, no. 3, pp. 714-730.e22. https://doi.org/10.1016/j.cell.2019.06.029

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AU - Smillie, Christopher S.

AU - Biton, Moshe

AU - Ordovas-Montanes, Jose

AU - Sullivan, Keri M.

AU - Burgin, Grace

AU - Graham, Daniel B.

AU - Herbst, Rebecca H.

AU - Rogel, Noga

AU - Slyper, Michal

AU - Waldman, Julia

AU - Sud, Malika

AU - Andrews, Elizabeth

AU - Velonias, Gabriella

AU - Haber, Adam L.

AU - Jagadeesh, Karthik

AU - Vickovic, Sanja

AU - Yao, Junmei

AU - Stevens, Christine

AU - Dionne, Danielle

AU - Nguyen, Lan T.

AU - Villani, Alexandra Chloé

AU - Hofree, Matan

AU - Creasey, Elizabeth A.

AU - Huang, Hailiang

AU - Rozenblatt-Rosen, Orit

AU - Garber, John J.

AU - Khalili, Hamed

AU - Desch, A. Nicole

AU - Daly, Mark J.

AU - Ananthakrishnan, Ashwin N.

AU - Shalek, Alex K.

AU - Xavier, Ramnik J.

AU - Regev, Aviv

PY - 2019/7/25

Y1 - 2019/7/25

N2 - Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

AB - Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

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KW - cell-cell interactions

KW - colon

KW - genome-wide association studies

KW - inflammation

KW - inflammatory bowel disease

KW - large intestine

KW - single-cell RNA-seq

KW - single-cell genomics

KW - ulcerative colitis

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VL - 178

SP - 714-730.e22

JO - Cell

JF - Cell

IS - 3

ER -

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Abstract

Bibliographical note

Keywords

UN SDGs

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