Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie; Moshe Biton; Jose Ordovas-Montanes; Keri M. Sullivan; Grace Burgin; Daniel B. Graham; Rebecca H. Herbst; Noga Rogel; Michal Slyper; Julia Waldman; Malika Sud; Elizabeth Andrews; Gabriella Velonias; Adam L. Haber; Karthik Jagadeesh; Sanja Vickovic; Junmei Yao; Christine Stevens; Danielle Dionne; Lan T. Nguyen; Alexandra Chloé Villani; Matan Hofree; Elizabeth A. Creasey; Hailiang Huang; Orit Rozenblatt-Rosen; John J. Garber; Hamed Khalili; A. Nicole Desch; Mark J. Daly; Ashwin N. Ananthakrishnan; Alex K. Shalek; Ramnik J. Xavier; Aviv Regev

doi:10.1016/j.cell.2019.06.029

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie
, Moshe Biton
, Jose Ordovas-Montanes
, Keri M. Sullivan
, Grace Burgin
, Daniel B. Graham
, Rebecca H. Herbst
, Noga Rogel
, Michal Slyper
, Julia Waldman
, Malika Sud
, Elizabeth Andrews
, Gabriella Velonias
, Adam L. Haber
, Karthik Jagadeesh
, Sanja Vickovic
, Junmei Yao
, Christine Stevens
, Danielle Dionne
, Lan T. Nguyen

Alexandra Chloé Villani, Matan Hofree, Elizabeth A. Creasey, Hailiang Huang, Orit Rozenblatt-Rosen, John J. Garber, Hamed Khalili, A. Nicole Desch, Mark J. Daly, Ashwin N. Ananthakrishnan^*, Alex K. Shalek, Ramnik J. Xavier, Aviv Regev

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1012 Scopus citations

Abstract

Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

Original language	English
Pages (from-to)	714-730.e22
Journal	Cell
Volume	178
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.06.029
State	Published - 25 Jul 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anti-TNF resistance
cell-cell interactions
colon
genome-wide association studies
inflammation
inflammatory bowel disease
large intestine
single-cell RNA-seq
single-cell genomics
ulcerative colitis

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10.1016/j.cell.2019.06.029

Cite this

Smillie, C. S., Biton, M., Ordovas-Montanes, J., Sullivan, K. M., Burgin, G., Graham, D. B., Herbst, R. H., Rogel, N., Slyper, M., Waldman, J., Sud, M., Andrews, E., Velonias, G., Haber, A. L., Jagadeesh, K., Vickovic, S., Yao, J., Stevens, C., Dionne, D., ... Regev, A. (2019). Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis. Cell, 178(3), 714-730.e22. https://doi.org/10.1016/j.cell.2019.06.029

@article{579c8cbfcfd24ad2a3ae8edc4009c10c,

title = "Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis",

abstract = "Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.",

keywords = "anti-TNF resistance, cell-cell interactions, colon, genome-wide association studies, inflammation, inflammatory bowel disease, large intestine, single-cell RNA-seq, single-cell genomics, ulcerative colitis",

author = "Smillie, \{Christopher S.\} and Moshe Biton and Jose Ordovas-Montanes and Sullivan, \{Keri M.\} and Grace Burgin and Graham, \{Daniel B.\} and Herbst, \{Rebecca H.\} and Noga Rogel and Michal Slyper and Julia Waldman and Malika Sud and Elizabeth Andrews and Gabriella Velonias and Haber, \{Adam L.\} and Karthik Jagadeesh and Sanja Vickovic and Junmei Yao and Christine Stevens and Danielle Dionne and Nguyen, \{Lan T.\} and Villani, \{Alexandra Chlo{\'e}\} and Matan Hofree and Creasey, \{Elizabeth A.\} and Hailiang Huang and Orit Rozenblatt-Rosen and Garber, \{John J.\} and Hamed Khalili and Desch, \{A. Nicole\} and Daly, \{Mark J.\} and Ananthakrishnan, \{Ashwin N.\} and Shalek, \{Alex K.\} and Xavier, \{Ramnik J.\} and Aviv Regev",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "25",

doi = "10.1016/j.cell.2019.06.029",

language = "אנגלית",

volume = "178",

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Smillie, CS, Biton, M, Ordovas-Montanes, J, Sullivan, KM, Burgin, G, Graham, DB, Herbst, RH, Rogel, N, Slyper, M, Waldman, J, Sud, M, Andrews, E, Velonias, G, Haber, AL, Jagadeesh, K, Vickovic, S, Yao, J, Stevens, C, Dionne, D, Nguyen, LT, Villani, AC, Hofree, M, Creasey, EA, Huang, H, Rozenblatt-Rosen, O, Garber, JJ, Khalili, H, Desch, AN, Daly, MJ, Ananthakrishnan, AN, Shalek, AK, Xavier, RJ & Regev, A 2019, 'Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis', Cell, vol. 178, no. 3, pp. 714-730.e22. https://doi.org/10.1016/j.cell.2019.06.029

TY - JOUR

T1 - Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

AU - Smillie, Christopher S.

AU - Biton, Moshe

AU - Ordovas-Montanes, Jose

AU - Sullivan, Keri M.

AU - Burgin, Grace

AU - Graham, Daniel B.

AU - Herbst, Rebecca H.

AU - Rogel, Noga

AU - Slyper, Michal

AU - Waldman, Julia

AU - Sud, Malika

AU - Andrews, Elizabeth

AU - Velonias, Gabriella

AU - Haber, Adam L.

AU - Jagadeesh, Karthik

AU - Vickovic, Sanja

AU - Yao, Junmei

AU - Stevens, Christine

AU - Dionne, Danielle

AU - Nguyen, Lan T.

AU - Villani, Alexandra Chloé

AU - Hofree, Matan

AU - Creasey, Elizabeth A.

AU - Huang, Hailiang

AU - Rozenblatt-Rosen, Orit

AU - Garber, John J.

AU - Khalili, Hamed

AU - Desch, A. Nicole

AU - Daly, Mark J.

AU - Ananthakrishnan, Ashwin N.

AU - Shalek, Alex K.

AU - Xavier, Ramnik J.

AU - Regev, Aviv

PY - 2019/7/25

Y1 - 2019/7/25

N2 - Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

AB - Single-cell analyses of colon biopsy specimens from patients with ulcerative colitis delineate how expression patterns and shifting cell populations may shape disease and drug resistance, and provide a framework for linking GWAS risk loci with specific cell types and functional pathways.

KW - anti-TNF resistance

KW - cell-cell interactions

KW - colon

KW - genome-wide association studies

KW - inflammation

KW - inflammatory bowel disease

KW - large intestine

KW - single-cell RNA-seq

KW - single-cell genomics

KW - ulcerative colitis

UR - https://www.scopus.com/pages/publications/85069176109

U2 - 10.1016/j.cell.2019.06.029

DO - 10.1016/j.cell.2019.06.029

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C2 - 31348891

AN - SCOPUS:85069176109

SN - 0092-8674

VL - 178

SP - 714-730.e22

JO - Cell

JF - Cell

IS - 3

ER -

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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