Intra-protein interactions across a fluid membrane as a model for biological transport

W. D. Stein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A model is proposed for the mechanism of action of the glucose transport system of the human erythrocyte. The model is based on the possibility of there being interaction through the membrane between superficially disposed protein subunits, these units being embedded within the bimolecular lipid layer, anchored to the aqueous phase, perhaps mobile in the plane of each face of the membrane. The subunits have the ability to bind sugar and, when associated with the symmetrical protein at the opposite face of the membrane, transfer sugar across the membrane. Evidence for the model is presented. The possibility that this model may also be a model for the cell membrane as such is briefly touched upon.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalJournal of General Physiology
Volume54
Issue number1
DOIs
StatePublished - 1 Jul 1969
Externally publishedYes

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