Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Saran Kumar, Husni Sharife, Tirzah Kreisel, Maxim Mogilevsky, Libat Bar-Lev, Myriam Grunewald, Elina Aizenshtein, Rotem Karni, Iddo Paldor, Tomer Shlomi, Eli Keshet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

Original languageAmerican English
Pages (from-to)201-211.e6
JournalCell Metabolism
Volume30
Issue number1
DOIs
StatePublished - 2 Jul 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • blood vessels
  • glioblastoma
  • mTOR pathway
  • metabolic compartmentalization
  • tumor heterogeneity
  • tumor microenvironment
  • tumor vasculature

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