Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Saran Kumar; Husni Sharife; Tirzah Kreisel; Maxim Mogilevsky; Libat Bar-Lev; Myriam Grunewald; Elina Aizenshtein; Rotem Karni; Iddo Paldor; Tomer Shlomi; Eli Keshet

doi:10.1016/j.cmet.2019.04.003

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Saran Kumar
, Husni Sharife
, Tirzah Kreisel
, Maxim Mogilevsky
, Libat Bar-Lev
, Myriam Grunewald
, Elina Aizenshtein
, Rotem Karni
, Iddo Paldor
, Tomer Shlomi
, Eli Keshet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

Original language	English
Pages (from-to)	201-211.e6
Journal	Cell Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.04.003
State	Published - 2 Jul 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

blood vessels
glioblastoma
mTOR pathway
metabolic compartmentalization
tumor heterogeneity
tumor microenvironment
tumor vasculature

Access to Document

10.1016/j.cmet.2019.04.003

Cite this

@article{02fa6b543ebd433fac248f44fd076f6f,

title = "Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity",

abstract = "Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.",

keywords = "blood vessels, glioblastoma, mTOR pathway, metabolic compartmentalization, tumor heterogeneity, tumor microenvironment, tumor vasculature",

author = "Saran Kumar and Husni Sharife and Tirzah Kreisel and Maxim Mogilevsky and Libat Bar-Lev and Myriam Grunewald and Elina Aizenshtein and Rotem Karni and Iddo Paldor and Tomer Shlomi and Eli Keshet",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.cmet.2019.04.003",

language = "אנגלית",

volume = "30",

pages = "201--211.e6",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

AU - Kumar, Saran

AU - Sharife, Husni

AU - Kreisel, Tirzah

AU - Mogilevsky, Maxim

AU - Bar-Lev, Libat

AU - Grunewald, Myriam

AU - Aizenshtein, Elina

AU - Karni, Rotem

AU - Paldor, Iddo

AU - Shlomi, Tomer

AU - Keshet, Eli

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

AB - Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

KW - blood vessels

KW - glioblastoma

KW - mTOR pathway

KW - metabolic compartmentalization

KW - tumor heterogeneity

KW - tumor microenvironment

KW - tumor vasculature

UR - https://www.scopus.com/pages/publications/85067351666

U2 - 10.1016/j.cmet.2019.04.003

DO - 10.1016/j.cmet.2019.04.003

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 31056286

AN - SCOPUS:85067351666

SN - 1550-4131

VL - 30

SP - 201-211.e6

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this