Intracellular Calcium Dynamics-Sparks Of Insight

D. Kraus, S. Khoury, A. Fendyur, S.G. Kachalsky, T. Abu-Hatoum, R. Rahamimoff

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Calcium ions are of key importance in a large number of cellular functions. In the past decade a large variety of cells have been found to show localized increases in the intracellular calcium concentration named calcium sparks. In this brief review, the methodology of detecting calcium sparks by confocal microscopy is summarized. Some of the properties of calcium sparks in muscle (cardiac, skeletal and smooth muscles), neurons, nerve terminals and oocytes are described. Speculations are put forward regarding their possible role in microcontrol of cell function. © 2011, by Walter de Gruyter GmbH & Co. All rights reserved.
Original languageEnglish
Pages (from-to)331-366
Number of pages36
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number4
StatePublished - 2000

Bibliographical note

Cited By :4

Export Date: 11 September 2022

Correspondence Address: Rahamimoff, R.; Department of Physiology, P.O. Box 12272, Jerusalem 91120, Israel

Chemicals/CAS: Calcium, 7440-70-2

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  • calcium noise
  • calcium puffs
  • calcium signaling
  • calcium sparks
  • cardiac muscle
  • confocal microscopy
  • endoplasmic reticulum
  • hippocampal cells in culture
  • intracellular calcium dynamics
  • mitochondria
  • oocytes
  • presynaptic bouton
  • sarcoplasmic reticulum
  • skeletal muscle
  • smooth muscle
  • transmitter release
  • calcium
  • calcium binding protein
  • calcium channel L type
  • calcium channel R type
  • animal cell
  • article
  • calcium cell level
  • calcium mobilization
  • calcium transport
  • Golgi complex
  • heart function
  • mitochondrion
  • nerve
  • nonhuman
  • oocyte
  • secretory granule
  • Animals
  • Calcium
  • Calcium Signaling
  • Humans


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