Intracellular Calcium Dynamics-Sparks Of Insight

D. Kraus, S. Khoury, A. Fendyur, S. G. Kachalsky, T. Abu-Hatoum, R. Rahamimoff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Calcium ions are of key importance in a large number of cellular functions. In the past decade a large variety of cells have been found to show localized increases in the intracellular calcium concentration named calcium sparks. In this brief review, the methodology of detecting calcium sparks by confocal microscopy is summarized. Some of the properties of calcium sparks in muscle (cardiac, skeletal and smooth muscles), neurons, nerve terminals and oocytes are described. Speculations are put forward regarding their possible role in microcontrol of cell function.

Original languageAmerican English
Pages (from-to)331-366
Number of pages36
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number4
StatePublished - 2000


  • calcium noise
  • calcium puffs
  • calcium signaling
  • calcium sparks
  • cardiac muscle
  • confocal microscopy
  • endoplasmic reticulum
  • hippocampal cells in culture
  • intracellular calcium dynamics
  • mitochondria
  • oocytes
  • presynaptic bouton
  • sarcoplasmic reticulum
  • skeletal muscle
  • smooth muscle
  • transmitter release


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