Intracellular TLR4 Signaling

Nikolay N. Kuzmich*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.

Original languageEnglish
Title of host publicationProgress in Inflammation Research
PublisherSpringer Nature
Pages21-37
Number of pages17
DOIs
StatePublished - 2021
Externally publishedYes

Publication series

NameProgress in Inflammation Research
Volume87
ISSN (Print)1422-7746
ISSN (Electronic)2296-4525

Bibliographical note

Publisher Copyright:
© 2021, Springer Nature Switzerland AG.

Keywords

  • Adaptor proteins
  • IRF3
  • NF-κB
  • Signal transduction
  • TLR4

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