Abstract
Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
Original language | English |
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Title of host publication | Progress in Inflammation Research |
Publisher | Springer Nature |
Pages | 21-37 |
Number of pages | 17 |
DOIs | |
State | Published - 2021 |
Externally published | Yes |
Publication series
Name | Progress in Inflammation Research |
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Volume | 87 |
ISSN (Print) | 1422-7746 |
ISSN (Electronic) | 2296-4525 |
Bibliographical note
Publisher Copyright:© 2021, Springer Nature Switzerland AG.
Keywords
- Adaptor proteins
- IRF3
- NF-κB
- Signal transduction
- TLR4