Intracellular TLR4 Signaling

Nikolay N. Kuzmich

doi:10.1007/978-3-030-56319-6_2

Intracellular TLR4 Signaling

Nikolay N. Kuzmich^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.

Original language	English
Title of host publication	Progress in Inflammation Research
Publisher	Springer Nature
Pages	21-37
Number of pages	17
DOIs	https://doi.org/10.1007/978-3-030-56319-6_2
State	Published - 2021
Externally published	Yes

Publication series

Name	Progress in Inflammation Research
Volume	87
ISSN (Print)	1422-7746
ISSN (Electronic)	2296-4525

Bibliographical note

Publisher Copyright:
© 2021, Springer Nature Switzerland AG.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adaptor proteins
IRF3
NF-κB
Signal transduction
TLR4

Access to Document

10.1007/978-3-030-56319-6_2

Cite this

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title = "Intracellular TLR4 Signaling",

abstract = "Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.",

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KW - Adaptor proteins

KW - IRF3

KW - NF-κB

KW - Signal transduction

KW - TLR4

UR - https://www.scopus.com/pages/publications/85131131190

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ER -

Intracellular TLR4 Signaling

Abstract

Publication series

Bibliographical note

UN SDGs

Keywords

Access to Document

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Cite this