Intracerebral HIV glycoprotein (gp120) enhances tumor metastasis via centrally released interleukin-1

Deborah M. Hodgson*, Raz Yirmiya, Francesco Chiappelli, Anna N. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Infection with the human immunodeficiency virus (HIV) is associated with a high incidence of cancers. This relationship does not appear to be due to a direct effect of the virus, and may be mediated by neuroimmune interactions since the HIV glycoprotein, gp120, enters the brain soon after infection with HIV, and intracerebroventricular (i.c.v.) infusion of gp120 suppresses aspects of cellular and tumor immunity. It has been speculated that this suppression may be attributed to the release of interleukin-1 (IL-1) in the brain induced by gp120. Using an in vivo tumor model, we examined the effect of centrally administered gp120 on tumor metastasis and lung clearance of mammary adenocarcinoma (MADB106) tumor cells in rats, and the role played by brain IL-1 in mediating these effects. We demonstrate that central administration of gp120 (4 μg) significantly (p < 0.05) increased the retention of tumor cells in the lungs and significantly (p < 0.02) enhanced the development of tumor metastases. Central administration of IL-1β (10 ng) also significantly (p < 0.05) increased retention of tumor cells in the lungs. The effect of gp120 on lung retention of tumor cells was blocked by co-administration of α-melanocyte stimulating hormone (α-MSH, 20 ng), a hormone that blocks many of the biological effects of IL-1, or the IL-1 receptor antagonist (50 μg). Given that systemic administration of gp120 or IL-1β had no effect on the retention of tumor cells in the lungs, these findings indicate that gp120-induced secretion of IL-1 within the brain most likely mediates the effects of gp120 on tumor metastasis. These findings suggest a possible neuroimmune mechanism to account for the increased incidence and aggressiveness of tumors in HIV-infected patients.

Original languageAmerican English
Pages (from-to)244-251
Number of pages8
JournalBrain Research
Issue number1-2
StatePublished - 19 Jan 1998

Bibliographical note

Funding Information:
This research was supported by The Norman Cousins Program in Psychoneuroimmunology at UCLA (D.M.H.), Department of Veterans Affairs Medical Research Service, NIH/NIAAA AA09850, and the US–Israel Binational Science Foundation 94-00062 (R.Y and A.N.T). We also acknowledge the generous donation of IL-1 from the National Cancer Institute (Biological Response Modifiers Program, NIH/NCI) and IL-1 receptor antagonist from AMGEN (Boulder, CO, USA). The expert technical assistance of Mr. Ngy Heng and Khai Nguyen was also greatly appreciated.


  • HIV
  • IL-1
  • MADB106
  • Metastasis
  • Tumor
  • gp120


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