Invasive adenylate cyclase toxin of Bordetella pertussis

Emanuel Hanski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Bordetella pertussis produces an adenylate cyclase which is a toxin. The enzyme penetrates eukaryotic cells and, upon activation by host calmodulin, generates high levels of intracellular cAMP; as a result bactericidal functions of immune effector cells are considerably impaired. The toxin is composed of a single polypeptide that possesses both the catalytic and the toxic functions. It penetrates the host cell directly from the plasma membrane and is concomitantly inactivated by a proteolytic degradation.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalTrends in Biochemical Sciences
Volume14
Issue number11
DOIs
StatePublished - Nov 1989
Externally publishedYes

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