Investigating and correcting plasma DNA sequencing coverage bias to enhance aneuploidy discovery

Keyphrases

• DNA Sequencing 100%
• Aneuploidy 100%
• Sequence Coverage 100%
• Coverage Bias 100%
• Fetal Trisomy 100%
• Plasma DNA 100%
• Trisomy 21 66%
• Next-generation Sequencing 33%
• DNA Fragments 33%
• Diagnostic Test 33%
• High Sensitivity 33%
• Sequence Data 33%
• Pregnant Women 33%
• DNA Motif 33%
• Down Syndrome 33%
• Statistical Test 33%
• Non-self 33%
• Bias Correction 33%
• Fetus 33%
• Cell-free DNA (cfDNA) 33%
• High Specificity 33%
• Detection Protocol 33%
• Clinical Test 33%
• GC Bias 33%
• Copy number Variation Detection 33%
• Genomic Repeats 33%
• Position-specific 33%
• Maternal Plasma 33%
• Gene Copy number Variation 33%
• Read Coverage 33%

Biochemistry, Genetics and Molecular Biology

• DNA Sequence 100%
• Aneuploidy 100%
• Trisomy 100%
• Blood Plasma 100%
• Trisomy 21 66%
• Next Generation Sequencing 33%
• Down Syndrome 33%
• Copy-Number Variation 33%
• Statistical Test 33%
• Genomics 33%