Investigating the Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) Among Patients Admitted to the Intensive Care Unit

Sima L. Sharara; Patricia J. Simner; Yehudit Bergman; Emily Jacobs; Suiyini Fiawoo; Eili Y. Klein; Sara E. Cosgrove; Pranita D. Tamma

doi:10.1093/ofid/ofaf590

Investigating the Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) Among Patients Admitted to the Intensive Care Unit

Sima L. Sharara^*
, Patricia J. Simner
, Yehudit Bergman
, Emily Jacobs
, Suiyini Fiawoo
, Eili Y. Klein
, Sara E. Cosgrove
, Pranita D. Tamma^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

At a United States hospital, sequencing of ICU rectal surveillance cultures indicated 5% ESBL-E colonization. Of confirmed ESBL isolates, 91% were Escherichia coli or Klebsiella pneumoniae; 6% carried non-bla _CTX-M genes. Only 53% of third-generation cephalosporin-resistant Enterobacterales harbored ESBL genes, underscoring the limitations of phenotypic approaches as ESBL surrogates, particularly for non-E. coli/K. pneumoniae species.

Original language	English
Article number	ofaf590
Journal	Open Forum Infectious Diseases
Volume	12
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofaf590
State	Published - 1 Oct 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CTX-M
ESBL-E
Escherichia coli
ICU admission
colonization

Access to Document

10.1093/ofid/ofaf590

Cite this

Sharara, S. L., Simner, P. J., Bergman, Y., Jacobs, E., Fiawoo, S., Klein, E. Y., Cosgrove, S. E., & Tamma, P. D. (2025). Investigating the Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) Among Patients Admitted to the Intensive Care Unit. Open Forum Infectious Diseases, 12(10), Article ofaf590. https://doi.org/10.1093/ofid/ofaf590

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abstract = "At a United States hospital, sequencing of ICU rectal surveillance cultures indicated 5\% ESBL-E colonization. Of confirmed ESBL isolates, 91\% were Escherichia coli or Klebsiella pneumoniae; 6\% carried non-bla CTX-M genes. Only 53\% of third-generation cephalosporin-resistant Enterobacterales harbored ESBL genes, underscoring the limitations of phenotypic approaches as ESBL surrogates, particularly for non-E. coli/K. pneumoniae species.",

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doi = "10.1093/ofid/ofaf590",

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AU - Simner, Patricia J.

AU - Bergman, Yehudit

AU - Jacobs, Emily

AU - Fiawoo, Suiyini

AU - Klein, Eili Y.

AU - Cosgrove, Sara E.

AU - Tamma, Pranita D.

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AB - At a United States hospital, sequencing of ICU rectal surveillance cultures indicated 5% ESBL-E colonization. Of confirmed ESBL isolates, 91% were Escherichia coli or Klebsiella pneumoniae; 6% carried non-bla CTX-M genes. Only 53% of third-generation cephalosporin-resistant Enterobacterales harbored ESBL genes, underscoring the limitations of phenotypic approaches as ESBL surrogates, particularly for non-E. coli/K. pneumoniae species.

KW - CTX-M

KW - ESBL-E

KW - Escherichia coli

KW - ICU admission

KW - colonization

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Investigating the Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) Among Patients Admitted to the Intensive Care Unit

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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