Investigating the transition from recent to remote memory using advanced tools

Adi Doron, Inbal Goshen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Remote memories, weeks to decades long, are usually the ones most important to the organism, as the longevity of a memory is tightly connected to its significance. Retrograde amnesia studies in human patients as well as lesions and immediate early gene expression investigation in animal models, suggested that the hippocampus has a time dependent role in memory consolidation. Namely, that as a memory matures it becomes independent of the hippocampus and instead depends on extra-hippocampal areas. However, accumulating evidence implies that this temporal segregation is not as rigid as originally proposed. In this review we will focus on the integration of new methods, such as chemogenetics, optogenetics and calcium imaging, which enable genetic specificity as well as high temporal and spatial resolution. Using these methods, recent studies have started to resolve the inconsistencies of past findings by observing and manipulating neural ensembles in different brain regions. We then discuss how these techniques can be applied to investigate the cellular underpinnings of memory across multiple time points, and employed to study the contribution of various cell types to remote memory.

Original languageAmerican English
Pages (from-to)35-43
Number of pages9
JournalBrain Research Bulletin
Volume141
DOIs
StatePublished - Jul 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

  • Calcium imaging
  • Chemogenetics
  • Contextual fear conditioning
  • Optogenetics
  • Remote memory
  • Systems consolidation

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