Investigation of field desorption mass spectral behaviour of prostaglandins for their determination in biological fluids

J. Deutsch*, D. Rachmilewitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Field desorption (FD) mass spectrometry was applied to the determination of prostaglandin E2 (PGE2) in urine. Studies on synthetic compounds showed that methyl esters are stable under FD mass spectrometric conditions. The ester of PGE2 gives rise to protonated molecular ions and fragments due to the elimination of water and the side chains C8H14O and C8H12O2. This behaviour enabled its determination in the nanogram per millilitre range.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalBiological Mass Spectrometry
Volume16
Issue number1-12
DOIs
StatePublished - Oct 1988

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