Involvement of autoimmunity in the pathogenesis of aggressive periodontitis

A. Hendler; T. K. Mulli; F. J. Hughes; D. Perrett; M. Bombardieri; Y. Houri-Haddad; E. I. Weiss; A. Nissim

doi:10.1177/0022034510381903

Involvement of autoimmunity in the pathogenesis of aggressive periodontitis

A. Hendler, T. K. Mulli, F. J. Hughes, D. Perrett, M. Bombardieri, Y. Houri-Haddad, E. I. Weiss, A. Nissim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of peri- odontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modi- fied by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

Original language	English
Pages (from-to)	1389-1394
Number of pages	6
Journal	Journal of Dental Research
Volume	89
Issue number	12
DOIs	https://doi.org/10.1177/0022034510381903
State	Published - Dec 2010
Externally published	Yes

Bibliographical note

Funding Information:
We thank Prof. Itzhak Ofek for critically reviewing the manuscript. Support for this research was provided by Queen Mary University and Hadassah Medical School.

Keywords

ROS
collagen type I
collagen type III
periodontitis

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title = "Involvement of autoimmunity in the pathogenesis of aggressive periodontitis",

abstract = "The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of peri- odontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modi- fied by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.",

keywords = "ROS, collagen type I, collagen type III, periodontitis",

author = "A. Hendler and Mulli, {T. K.} and Hughes, {F. J.} and D. Perrett and M. Bombardieri and Y. Houri-Haddad and Weiss, {E. I.} and A. Nissim",

note = "Funding Information: We thank Prof. Itzhak Ofek for critically reviewing the manuscript. Support for this research was provided by Queen Mary University and Hadassah Medical School.",

year = "2010",

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doi = "10.1177/0022034510381903",

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AU - Mulli, T. K.

AU - Hughes, F. J.

AU - Perrett, D.

AU - Bombardieri, M.

AU - Houri-Haddad, Y.

AU - Weiss, E. I.

AU - Nissim, A.

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N2 - The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of peri- odontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modi- fied by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

AB - The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of peri- odontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modi- fied by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

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Involvement of autoimmunity in the pathogenesis of aggressive periodontitis

Abstract

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