Involvement of autoimmunity in the pathogenesis of aggressive periodontitis

A. Hendler, T. K. Mulli, F. J. Hughes, D. Perrett, M. Bombardieri, Y. Houri-Haddad, E. I. Weiss, A. Nissim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of peri- odontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modi- fied by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

Original languageAmerican English
Pages (from-to)1389-1394
Number of pages6
JournalJournal of Dental Research
Volume89
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank Prof. Itzhak Ofek for critically reviewing the manuscript. Support for this research was provided by Queen Mary University and Hadassah Medical School.

Keywords

  • ROS
  • collagen type I
  • collagen type III
  • periodontitis

Fingerprint

Dive into the research topics of 'Involvement of autoimmunity in the pathogenesis of aggressive periodontitis'. Together they form a unique fingerprint.

Cite this