TY - JOUR
T1 - Involvement of spectrin in membrane fusion
T2 - Induction of fusion in human erythrocyte ghosts by proteolytic enzymes and its inhibition by antispectrin antibody
AU - Lalazar, A.
AU - Loyter, A.
PY - 1979
Y1 - 1979
N2 - In contrast to intact human erythrocytes, human erythrocyte ghosts can be agglutinated but not fused by Sendai virus. Membrane fusion can, however, be induced in virus-agglutinated erythrocyte ghosts by addition of proteolytic enzymes such as trypsin, papain, or Pronase. When erythrocyte ghosts were reacted with antispectrin antiserum, the antiserum inhibited both the induction of fusion and the proteolysis of the membrane spectrin. The correlation between the membrane fusion process and the membrane cytoskeleton is discussed.
AB - In contrast to intact human erythrocytes, human erythrocyte ghosts can be agglutinated but not fused by Sendai virus. Membrane fusion can, however, be induced in virus-agglutinated erythrocyte ghosts by addition of proteolytic enzymes such as trypsin, papain, or Pronase. When erythrocyte ghosts were reacted with antispectrin antiserum, the antiserum inhibited both the induction of fusion and the proteolysis of the membrane spectrin. The correlation between the membrane fusion process and the membrane cytoskeleton is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0018378067&partnerID=8YFLogxK
U2 - 10.1073/pnas.76.1.318
DO - 10.1073/pnas.76.1.318
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C2 - 218196
AN - SCOPUS:0018378067
SN - 0027-8424
VL - 76
SP - 318
EP - 322
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 1
ER -