Iontophoretically applied corticosteroids do not affect the firing of hippocampal neurons

Y. B. Barak, M. J. Gutnick, S. Feldman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In view of the possible role of the hippocampus in the neuroendocrine regulation of ACTH secretion, experiments were conducted in rats and cats in which cortisol (C) and corticosterone (CS) were applied by iontophoresis and pressure microinjection while recording from single identified pyramidal cells in the dorsal hippocampus, using multibarrelled microelectrodes. None of the more than 500 cells tested responded with a significant change in firing rate. The possible relation of these findings to neuroendocrine regulation of ACTH secretion is discussed.

Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalNeuroendocrinology
Volume23
Issue number4
DOIs
StatePublished - 1977
Externally publishedYes

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