Abstract
This chapter presents results of studies on the role of iron in neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) using main tool Mössbauer spectroscopy, but also other complementary techniques such as electron microscopy, enzyme-linked immunosorbent assay (ELISA), and atomic absorption. The chapter present a short review on neurodegeneration and oxidative stress. It discusses the properties of iron-binding compounds in the normal human brain. The chapter compares the properties of iron present in normal tissues with those from the structures affected by the disease process. It summarizes the possible role of iron in the pathological processes of some neurodegenerative diseases of the human brain and ratio between the iron concentrations in substantia nigra (SN) of PD and control, as obtained by various methods from fresh frozen tissues.
Original language | English |
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Title of host publication | Mössbauer Spectroscopy |
Subtitle of host publication | Applications in Chemistry, Biology, and Nanotechnology |
Publisher | wiley |
Pages | 324-332 |
Number of pages | 9 |
ISBN (Electronic) | 9781118714614 |
ISBN (Print) | 9781118057247 |
DOIs | |
State | Published - 28 Oct 2013 |
Bibliographical note
Publisher Copyright:© 2014 by John Wiley & Sons, Inc.
Keywords
- Hemosiderin
- Human brain
- Iron
- Mössbauer spectroscopy
- Neurodegeneration
- Oxidative stress
- Substantia nigra (SN)