Iron In Neurodegeneration

Jolanta Gałazka-Friedman*, Erika R. Bauminger, Andrzej Friedman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

This chapter presents results of studies on the role of iron in neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) using main tool Mössbauer spectroscopy, but also other complementary techniques such as electron microscopy, enzyme-linked immunosorbent assay (ELISA), and atomic absorption. The chapter present a short review on neurodegeneration and oxidative stress. It discusses the properties of iron-binding compounds in the normal human brain. The chapter compares the properties of iron present in normal tissues with those from the structures affected by the disease process. It summarizes the possible role of iron in the pathological processes of some neurodegenerative diseases of the human brain and ratio between the iron concentrations in substantia nigra (SN) of PD and control, as obtained by various methods from fresh frozen tissues.

Original languageEnglish
Title of host publicationMössbauer Spectroscopy
Subtitle of host publicationApplications in Chemistry, Biology, and Nanotechnology
Publisherwiley
Pages324-332
Number of pages9
ISBN (Electronic)9781118714614
ISBN (Print)9781118057247
DOIs
StatePublished - 28 Oct 2013

Bibliographical note

Publisher Copyright:
© 2014 by John Wiley & Sons, Inc.

Keywords

  • Hemosiderin
  • Human brain
  • Iron
  • Mössbauer spectroscopy
  • Neurodegeneration
  • Oxidative stress
  • Substantia nigra (SN)

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