Iron in typical and atypical parkinsonism – Mössbauer spectroscopy and MRI studies

R. Kuliński, E. R. Bauminger, A. Friedman, P. Duda, J. Gałązka-Friedman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Iron may play important role in neurodegeneration. The results of comparative studies of human brain areas (control and pathological) performed by Mössbauer spectroscopy (MS) and magnetic resonance imaging (MRI) techniques are presented. Mössbauer spectroscopy demonstrated a higher concentration of iron in atypical parkinsonism (progressive supranuclear palsy PSP) in the brain areas Substantia Nigra (SN) and Globus Pallidus (GP) involved in this pathological process, compared to control, while the concentration of iron in pathological tissues in typical parkinsonism (Parkinson’s disease - PD) did not differ from that in control. These results were compared with the changes in 1/T1 and 1/T2 (T1 and T2 being the relaxation times determined by MRI). A good linear correlation curve was found between the concentration of iron as determined by MS in different areas of control human brains and between 1/T1 and 1/T2. Whereas the finding in PSP-GP (the brain area involved in PSP) also fitted to such a correlation, this was not so for the correlation between pathological SN – the brain area involved in both diseases – and 1/T2, indicating a dependence of T2 on other factors than just the concentration of iron.

Original languageEnglish
Article number4
Pages (from-to)1-8
Number of pages8
JournalHyperfine Interactions
Volume237
Issue number1
DOIs
StatePublished - 1 Dec 2016

Bibliographical note

Publisher Copyright:
© 2016, The Author(s).

Keywords

  • Brain iron
  • MRI relaxation times
  • Mössbauer spectroscopy
  • Parkinsonism

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