Iron overload and chelation

Chaim Hershko; Gabriela Link; Abraham M. Konijn; Z. Ioav Cabantchik

doi:10.1080/10245330512331390294

Iron overload and chelation

Chaim Hershko^*, Gabriela Link, Abraham M. Konijn, Z. Ioav Cabantchik

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form is extremely low. Hence, living organisms were compelled to develop efficient mechanisms for iron transport and storage.

Original language	English
Pages (from-to)	171-173
Number of pages	3
Journal	Hematology
Volume	10
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1080/10245330512331390294
State	Published - Sep 2005

Keywords

Deferiprone
Deferoxamine
ICL670
Iron chelation
NTBI
Thalassemia

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10.1080/10245330512331390294

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abstract = "Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form is extremely low. Hence, living organisms were compelled to develop efficient mechanisms for iron transport and storage.",

keywords = "Deferiprone, Deferoxamine, ICL670, Iron chelation, NTBI, Thalassemia",

author = "Chaim Hershko and Gabriela Link and Konijn, {Abraham M.} and Cabantchik, {Z. Ioav}",

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AB - Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form is extremely low. Hence, living organisms were compelled to develop efficient mechanisms for iron transport and storage.

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KW - Thalassemia

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Iron overload and chelation

Abstract

Keywords

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