TY - JOUR
T1 - Is herpes simplex virus associated with pulp/periapical inflammation?
AU - Heling, I.
AU - Morag-Hezroni, M.
AU - Marva, E.
AU - Hochman, N.
AU - Zakay-Rones, Z.
AU - Morag, A.
PY - 2001/3
Y1 - 2001/3
N2 - Objectives. This study focuses on the detection of herpes simplex virus (HSV) DNA in dental pulp and inflamed periapical tissue. Study design. Dental pulp tissue (vital and necrotic) and periapical tissue samples were collected under strictly sterile conditions and examined for the presence of HSV DNA. Saliva samples were also examined for the presence of the viral DNA. The polymerase chain reaction assay was used to detect viral DNA. Blood samples were collected, and the enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against HSV was carried out. Results. According to the ELISA test, 19 of the 23 blood samples were IgG-positive and IgM-negative to HSV, whereas 4 were IgG-negative and IgM-negative. HSV DNA was not detected in the tissue and the saliva samples tested. Conclusion. HSV is not present and therefore is probably not involved in the pathology of tooth neural tissue.
AB - Objectives. This study focuses on the detection of herpes simplex virus (HSV) DNA in dental pulp and inflamed periapical tissue. Study design. Dental pulp tissue (vital and necrotic) and periapical tissue samples were collected under strictly sterile conditions and examined for the presence of HSV DNA. Saliva samples were also examined for the presence of the viral DNA. The polymerase chain reaction assay was used to detect viral DNA. Blood samples were collected, and the enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against HSV was carried out. Results. According to the ELISA test, 19 of the 23 blood samples were IgG-positive and IgM-negative to HSV, whereas 4 were IgG-negative and IgM-negative. HSV DNA was not detected in the tissue and the saliva samples tested. Conclusion. HSV is not present and therefore is probably not involved in the pathology of tooth neural tissue.
UR - http://www.scopus.com/inward/record.url?scp=0035289910&partnerID=8YFLogxK
U2 - 10.1067/moe.2001.113162
DO - 10.1067/moe.2001.113162
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C2 - 11250636
AN - SCOPUS:0035289910
SN - 1079-2104
VL - 91
SP - 359
EP - 361
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
IS - 3
ER -