Is it necessary to wait several minutes between applications of different topical ophthalmic solutions? A preliminary study with tropicamide eye drops in healthy dogs

Dikla Arad, Reut Deckel, Oren Pe’er, Maya Ross, Lionel Sebbag, Ron Ofri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective: To evaluate the efficacy of topical tropicamide when placed at different time intervals before or after a saline drop. Animals studied: Eight healthy Labrador and golden retriever dogs. Procedures: The effect of 1% tropicamide on pupillary diameter (PD) was measured over 240 min when administered alone (control) and then 1 and 5 min prior to, or following, application of a saline drop, with 1-week washout between each of the five trials. Data were analyzed using repeated-measures ANOVA and Tukey post hoc test. Results: Only 6/110 pairwise comparisons among the 5 trials were statistically significant (p ≤.035), with post-hoc analysis showing no significant differences (p ≥.14) between the overall means of all trials. In all five trials, maximal PD was reached 30 min after tropicamide application and maintained until 210 min for 180 min (p =.0005). Conclusions: Our results suggest that waiting 1 min between applications of different ophthalmic solutions may be sufficient for maximal drug effect. Care should be taken when extrapolating these results to other species and different ophthalmic formulations.

Original languageAmerican English
Pages (from-to)374-379
Number of pages6
JournalVeterinary Ophthalmology
Volume24
Issue number4
DOIs
StatePublished - Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 American College of Veterinary Ophthalmologists

Keywords

  • efficacy
  • eye drops
  • interval
  • ophthalmic solution
  • pupil
  • tropicamide

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