Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Larry D. Cowgill; David J. Polzin; Jonathan Elliott; Mary B. Nabity; Gilad Segev; Gregory F. Grauer; Scott Brown; Cathy Langston; Astrid M. van Dongen

doi:10.1016/j.cvsm.2016.06.001

Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Larry D. Cowgill^*, David J. Polzin, Jonathan Elliott, Mary B. Nabity, Gilad Segev, Gregory F. Grauer, Scott Brown, Cathy Langston, Astrid M. van Dongen

^*Corresponding author for this work

The Koret School of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

International Renal Interest Society chronic kidney disease Stage 1 and acute kidney injury Grade I categorizations of kidney disease are often confused or ignored because patients are nonazotemic and generally asymptomatic. Recent evidence suggests these seemingly disparate conditions may be mechanistically linked and interrelated. Active kidney injury biomarkers have the potential to establish a new understanding for traditional views of chronic kidney disease, including its early identification and possible mediators of its progression, which, if validated, would establish a new and sophisticated paradigm for the understanding and approach to the diagnostic evaluation, and treatment of urinary disease in dogs and cats.

Original language	American English
Pages (from-to)	995-1013
Number of pages	19
Journal	Veterinary Clinics of North America - Small Animal Practice
Volume	46
Issue number	6
DOIs	https://doi.org/10.1016/j.cvsm.2016.06.001
State	Published - 1 Nov 2016

Bibliographical note

Funding Information:
Disclosure: Dr L.D. Cowgill has served as a paid consultant for IDEXX Laboratories and CEVA Animal Health . He is a member of the Inernational Renal Interest Society and has received gift funding from IDEXX Laboratories to support his research. Dr J. Elliott has served as a paid consultant for Bayer Animal Health , Boehringer Ingelheim , Elanco Animal Health , Idexx Ltd , CEVA Animal Health, Orion Inc , Nextvet Ltd , and Waltham Centre for Pet Nutrition . He receives research grant funding from CEVA Animal Health, Elanco Animal Health, Zoetis Animal Health , Royal Canin , and Waltham Centre for Pet Nutrition. He is a member of the International Renal Interest Society. Drs D.J. Polzin, M.B. Nabity, G. Segev, G.F. Grauer, S. Brown, C. Langston, and A.M. van Dongen have nothing to disclose.

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

IRIS AKI grade I
IRIS CKD stage 1
Kidney biomarkers
Progressive chronic kidney disease

Access to Document

10.1016/j.cvsm.2016.06.001

Cite this

@article{2b124c33939441c7af95b117a903f75c,

title = "Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?",

abstract = "International Renal Interest Society chronic kidney disease Stage 1 and acute kidney injury Grade I categorizations of kidney disease are often confused or ignored because patients are nonazotemic and generally asymptomatic. Recent evidence suggests these seemingly disparate conditions may be mechanistically linked and interrelated. Active kidney injury biomarkers have the potential to establish a new understanding for traditional views of chronic kidney disease, including its early identification and possible mediators of its progression, which, if validated, would establish a new and sophisticated paradigm for the understanding and approach to the diagnostic evaluation, and treatment of urinary disease in dogs and cats.",

keywords = "IRIS AKI grade I, IRIS CKD stage 1, Kidney biomarkers, Progressive chronic kidney disease",

author = "Cowgill, {Larry D.} and Polzin, {David J.} and Jonathan Elliott and Nabity, {Mary B.} and Gilad Segev and Grauer, {Gregory F.} and Scott Brown and Cathy Langston and {van Dongen}, {Astrid M.}",

note = "Funding Information: Disclosure: Dr L.D. Cowgill has served as a paid consultant for IDEXX Laboratories and CEVA Animal Health . He is a member of the Inernational Renal Interest Society and has received gift funding from IDEXX Laboratories to support his research. Dr J. Elliott has served as a paid consultant for Bayer Animal Health , Boehringer Ingelheim , Elanco Animal Health , Idexx Ltd , CEVA Animal Health, Orion Inc , Nextvet Ltd , and Waltham Centre for Pet Nutrition . He receives research grant funding from CEVA Animal Health, Elanco Animal Health, Zoetis Animal Health , Royal Canin , and Waltham Centre for Pet Nutrition. He is a member of the International Renal Interest Society. Drs D.J. Polzin, M.B. Nabity, G. Segev, G.F. Grauer, S. Brown, C. Langston, and A.M. van Dongen have nothing to disclose. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.cvsm.2016.06.001",

language = "American English",

volume = "46",

pages = "995--1013",

journal = "Veterinary Clinics of North America - Small Animal Practice",

issn = "0195-5616",