Is there a prediction network? Meta-analytic evidence for a cortical-subcortical network likely subserving prediction

Tali Siman-Tov*, Roni Y. Granot, Ofir Shany, Neomi Singer, Talma Hendler, Carlos R. Gordon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Predictive coding is an increasingly influential and ambitious concept in neuroscience viewing the brain as a ‘hypothesis testing machine’ that constantly strives to minimize prediction error, the gap between its predictions and the actual sensory input. Despite the invaluable contribution of this framework to the formulation of brain function, its neuroanatomical foundations have not been fully defined. To address this gap, we conducted activation likelihood estimation (ALE) meta-analysis of 39 neuroimaging studies of three functional domains (action perception, language and music) inherently involving prediction. The ALE analysis revealed a widely distributed brain network encompassing regions within the inferior and middle frontal gyri, anterior insula, premotor cortex, pre-supplementary motor area, temporoparietal junction, striatum, thalamus/subthalamus and the cerebellum. This network is proposed to subserve domain-general prediction and its relevance to motor control, attention, implicit learning and social cognition is discussed in light of the predictive coding scheme. Better understanding of the presented network may help advance treatments of neuropsychiatric conditions related to aberrant prediction processing and promote cognitive enhancement in healthy individuals.

Original languageAmerican English
Pages (from-to)262-275
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
StatePublished - Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd


  • Action perception
  • Hierarchical
  • Language
  • Meta-analysis
  • Music
  • Network
  • Neuroimaging
  • Prediction
  • Prediction error
  • Predictive coding


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