Isolating human brain functional connectivity associated with a specific cognitive process

Michael A. Silver, Ayelet N. Landau, Thomas Z. Lauritzen, William Prinzmetal, Lynn C. Robertson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations


The use of functional magnetic resonance imaging (fMRI) to measure functional connectivity among brain areas has the potential to identify neural networks associated with particular cognitive processes. However, fMRI signals are not a direct measure of neural activity but rather represent blood oxygenation level-dependent (BOLD) signals. Correlated BOLD signals between two brain regions are therefore a combination of neural, neurovascular, and vascular coupling. Here, we describe a procedure for isolating brain functional connectivity associated with a specific cognitive process. Coherency magnitude (measuring the strength of coupling between two time series) and phase (measuring the temporal latency differences between two time series) are computed during performance of a particular cognitive task and also for a control condition. Subtraction of the coherency magnitude and phase differences for the two conditions removes sources of correlated BOLD signals that do not modulate as a function of cognitive task, resulting in a more direct measure of functional connectivity associated with changes in neuronal activity. We present two applications of this task subtraction procedure, one to measure changes in strength of coupling associated with sustained visual spatial attention, and one to measure changes in temporal latencies between brain areas associated with voluntary visual spatial attention.

Original languageAmerican English
Title of host publicationProceedings of SPIE-IS and T Electronic Imaging - Human Vision and Electronic Imaging XV
StatePublished - 2010
Externally publishedYes
EventHuman Vision and Electronic Imaging XV - San Jose, CA, United States
Duration: 18 Jan 201021 Jan 2010

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferenceHuman Vision and Electronic Imaging XV
Country/TerritoryUnited States
CitySan Jose, CA


  • Coherency
  • Functional connectivity
  • Occipital cortex
  • Parietal cortex
  • Visual attention
  • Visual cortex
  • Voluntary attention
  • fMRI


Dive into the research topics of 'Isolating human brain functional connectivity associated with a specific cognitive process'. Together they form a unique fingerprint.

Cite this