Abstract
γ Thiochromanone 4 thiosemicarbazone (TCT) inhibits the growth of vaccinia virus in BSCl cells by interfering with viral maturation. A mutant of the virus (TCT(R)) which is resistant to this drug was isolated. This mutant also exhibits resistance to another thiosemicarbazone related compound, isatin β thiosemicarbazone (IBT). There is a good correlation between the cross resistance of the two mutants IBT(R) and TCT(R) to TCT and IBT, respectively and the similar antipoxvirus activity of these two thiosemicarbazone related compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 85-90 |
| Number of pages | 6 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 7 |
| Issue number | 1 |
| State | Published - 1975 |