TY - JOUR
T1 - Isolation and characterization of herpes simplex virus resistant to nucleoside analogs
AU - Katz, Ehud
AU - Rosenblat, Orna
AU - Pisanty, Sara
PY - 1991/9
Y1 - 1991/9
N2 - Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2′-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2′-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient3/12 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.
AB - Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2′-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2′-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient3/12 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.
UR - http://www.scopus.com/inward/record.url?scp=0026070015&partnerID=8YFLogxK
U2 - 10.1016/0030-4220(91)90218-2
DO - 10.1016/0030-4220(91)90218-2
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C2 - 1656355
AN - SCOPUS:0026070015
SN - 0030-4220
VL - 72
SP - 296
EP - 299
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 3
ER -