Isolation and characterization of herpes simplex virus resistant to nucleoside analogs

Ehud Katz; Orna Rosenblat; Sara Pisanty

doi:10.1016/0030-4220(91)90218-2

Isolation and characterization of herpes simplex virus resistant to nucleoside analogs

Ehud Katz
, Orna Rosenblat
, Sara Pisanty^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2′-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2′-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient3/12 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.

Original language	English
Pages (from-to)	296-299
Number of pages	4
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/0030-4220(91)90218-2
State	Published - Sep 1991

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title = "Isolation and characterization of herpes simplex virus resistant to nucleoside analogs",

abstract = "Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2′-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2′-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient3/12 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.",

author = "Ehud Katz and Orna Rosenblat and Sara Pisanty",

year = "1991",

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doi = "10.1016/0030-4220(91)90218-2",

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AU - Rosenblat, Orna

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AB - Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2′-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2′-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient3/12 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.

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Isolation and characterization of herpes simplex virus resistant to nucleoside analogs

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