We present an ab initio study of the isoscalar monopole excitations of He4 using different realistic nuclear interactions, including modern effective field theory potentials. In particular we concentrate on the transition form factor FM to the narrow 0+ resonance close to threshold. F M exhibits a strong potential model dependence, and can serve as a kind of prism to distinguish among different nuclear force models. Compared to the measurements obtained from inelastic electron scattering off He4, one finds that the state-of-the-art theoretical transition form factors are at variance with experimental data, especially in the case of effective field theory potentials. We discuss some possible reasons for such a discrepancy, which still remains a puzzle.