Issledovanie vzaimodeǐstviia antitelo-gapten s pomoshch'iu izmereniia skorosti rasprostraneniia ul'trazvuka.

Translated title of the contribution: Study of antibody-hapten interaction by measuring velocity of ultrasound propagation

G. V. Shil'nikov*, A. I. Priev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The patterns of conformational changes induced in pig antibodies to 2,4-dinitrophenyllisin on binding with hapten were investigated by precise measurements of ultrasound velocity. It was shown that upon specific binding with intact antibodies, the observed slow changes of the bulk-clustic properties of the investigated solution reflect self-association of IgG molecules. In the case of interaction of Fab-fragments with hapten no changes of the acoustic properties were found. It was assumed that self-association is related to the increase in the hydrophobicity of Fe-fragments observed upon conformational changes of IgG molecules.

Translated title of the contributionStudy of antibody-hapten interaction by measuring velocity of ultrasound propagation
Original languageRussian
Pages (from-to)572-575
Number of pages4
JournalBiofizika
Volume33
Issue number4
StatePublished - Jul 1988

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