"Jumping translocation" in a 17-month-old child with mixed-lineage leukemia

Susana Ben-Neriah; Ayala Abramov; Israela Lerer; Aaron Polliack; Rachel Leizerowitz; Ruth Rabinowitz; Dvorah Abeliovich

doi:10.1016/0165-4608(91)90174-S

"Jumping translocation" in a 17-month-old child with mixed-lineage leukemia

Susana Ben-Neriah, Ayala Abramov, Israela Lerer, Aaron Polliack, Rachel Leizerowitz, Ruth Rabinowitz, Dvorah Abeliovich^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A 17-month-old child with acute biphenotypic (pre B-ALL/myelomonocytic) leukemia is reported. Extensive cytogenetic analysis performed at various stages of the disease revealed a clonal evolution at the time of initial diagnosis with two types of abnormal clones, one with trisomy 22 and two other related clones with trisomy 22 plus partial trisomy of the long arm of chromosome 1 associated with the telomeric segment of either chromosome 20q or 21p. At the time of relapse the only abnormal clone involved trisomy 22 and partial trisomy of 1q, but this time in association with the telomeric segment of 14p. The unique feature of these translocations is discussed and the possibility of the correlation between the different chromosomal abnormalities and the expression of biphenotypic markers is raised.

Original language	English
Pages (from-to)	223-229
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(91)90174-S
State	Published - 15 Oct 1991
Externally published	Yes

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abstract = "A 17-month-old child with acute biphenotypic (pre B-ALL/myelomonocytic) leukemia is reported. Extensive cytogenetic analysis performed at various stages of the disease revealed a clonal evolution at the time of initial diagnosis with two types of abnormal clones, one with trisomy 22 and two other related clones with trisomy 22 plus partial trisomy of the long arm of chromosome 1 associated with the telomeric segment of either chromosome 20q or 21p. At the time of relapse the only abnormal clone involved trisomy 22 and partial trisomy of 1q, but this time in association with the telomeric segment of 14p. The unique feature of these translocations is discussed and the possibility of the correlation between the different chromosomal abnormalities and the expression of biphenotypic markers is raised.",

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AU - Ben-Neriah, Susana

AU - Abramov, Ayala

AU - Lerer, Israela

AU - Polliack, Aaron

AU - Leizerowitz, Rachel

AU - Rabinowitz, Ruth

AU - Abeliovich, Dvorah

PY - 1991/10/15

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AB - A 17-month-old child with acute biphenotypic (pre B-ALL/myelomonocytic) leukemia is reported. Extensive cytogenetic analysis performed at various stages of the disease revealed a clonal evolution at the time of initial diagnosis with two types of abnormal clones, one with trisomy 22 and two other related clones with trisomy 22 plus partial trisomy of the long arm of chromosome 1 associated with the telomeric segment of either chromosome 20q or 21p. At the time of relapse the only abnormal clone involved trisomy 22 and partial trisomy of 1q, but this time in association with the telomeric segment of 14p. The unique feature of these translocations is discussed and the possibility of the correlation between the different chromosomal abnormalities and the expression of biphenotypic markers is raised.

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"Jumping translocation" in a 17-month-old child with mixed-lineage leukemia

Abstract

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