Jun proteins inhibit autophagy and induce cell death

Orli Yogev, Eitan Shaulian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Starvation induces a vigorous autophagic response to enhance cellular survival, whereas nutrient and serum supplementation inhibit autophagy and induce an intensive transcriptional burst that enables cellular proliferation. We recently found that some of the genes induced by serum and growth factors - the immediate early proteins JunB and c-Jun - inhibit autophagy. Deregulation of JunB expression, when autophagy is specifically required, tilts the fate of starved cells to apoptosis.

Original languageAmerican English
Pages (from-to)566-567
Number of pages2
JournalAutophagy
Volume6
Issue number4
DOIs
StatePublished - 16 May 2010

Keywords

  • AP-1
  • Apoptosis
  • Autophagy
  • JunB
  • c-Jun
  • mTOR

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