Jun proteins inhibit autophagy and induce cell death

Orli Yogev; Eitan Shaulian

doi:10.4161/auto.6.4.11950

Jun proteins inhibit autophagy and induce cell death

Orli Yogev, Eitan Shaulian^*

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Starvation induces a vigorous autophagic response to enhance cellular survival, whereas nutrient and serum supplementation inhibit autophagy and induce an intensive transcriptional burst that enables cellular proliferation. We recently found that some of the genes induced by serum and growth factors - the immediate early proteins JunB and c-Jun - inhibit autophagy. Deregulation of JunB expression, when autophagy is specifically required, tilts the fate of starved cells to apoptosis.

Original language	English
Pages (from-to)	566-567
Number of pages	2
Journal	Autophagy
Volume	6
Issue number	4
DOIs	https://doi.org/10.4161/auto.6.4.11950
State	Published - 16 May 2010

Keywords

AP-1
Apoptosis
Autophagy
JunB
c-Jun
mTOR

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10.4161/auto.6.4.11950

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AB - Starvation induces a vigorous autophagic response to enhance cellular survival, whereas nutrient and serum supplementation inhibit autophagy and induce an intensive transcriptional burst that enables cellular proliferation. We recently found that some of the genes induced by serum and growth factors - the immediate early proteins JunB and c-Jun - inhibit autophagy. Deregulation of JunB expression, when autophagy is specifically required, tilts the fate of starved cells to apoptosis.

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KW - Autophagy

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KW - c-Jun

KW - mTOR

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Jun proteins inhibit autophagy and induce cell death

Abstract

Keywords

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