K-space interpretation of image-scanning-microscopy

Tal I. Sommer, Gil Weinberg, Ori Katz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, image-scanning microscopy (ISM, also termed pixel-reassignment microscopy) has emerged as a technique that improves the resolution and signal-to-noise compared to confocal and widefield microscopy by employing a detector array at the image plane of a confocal laser scanning microscope. Here, we present a k-space analysis of coherent ISM, showing that ISM is equivalent to spotlight synthetic-aperture radar and analogous to oblique-illumination microscopy. This insight indicates that ISM can be performed with a single detector placed in the k-space of the sample, which we numerically demonstrate.

Original languageAmerican English
Article number141106
JournalApplied Physics Letters
Volume122
Issue number14
DOIs
StatePublished - 3 Apr 2023

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© 2023 Author(s).

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