TY - JOUR
T1 - Kaposi's sarcoma-associated herpesvirus
T2 - Clinical, diagnostic, and epidemiological aspects
AU - Cohen, Adina
AU - Wolf, Dana G.
AU - Guttman-Yassky, Emma
AU - Sarid, Ronit
PY - 2005/3
Y1 - 2005/3
N2 - Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of these studies are contradictory and are yet to be resolved. Concentrated effort over the last decade, since the initial discovery of KSHV, led to the development of several experimental systems that resulted in a better comprehension of the biological characteristics of KSHV and set the stage for the understanding of mechanisms by which diseases are induced by the virus. The development of molecular, histological, and serological tools for KSHV diagnosis allowed researchers to track the transmission and to study the epidemiology of KSHV. These assays have been applied, in particular in ambiguous cases, in order to confirm clinically and pathologically based diagnoses. Here, we review the advances in the clinical, experimental, diagnostic, and epidemiological research of KSHV.
AB - Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). Possible associations of KSHV with other clinical settings have been extensively examined. The findings from several of these studies are contradictory and are yet to be resolved. Concentrated effort over the last decade, since the initial discovery of KSHV, led to the development of several experimental systems that resulted in a better comprehension of the biological characteristics of KSHV and set the stage for the understanding of mechanisms by which diseases are induced by the virus. The development of molecular, histological, and serological tools for KSHV diagnosis allowed researchers to track the transmission and to study the epidemiology of KSHV. These assays have been applied, in particular in ambiguous cases, in order to confirm clinically and pathologically based diagnoses. Here, we review the advances in the clinical, experimental, diagnostic, and epidemiological research of KSHV.
KW - Human herpesvirus 8
KW - Kaposi's sarcoma
KW - Kaposi's sarcoma-associated herpesvirus
KW - Multicentric Castleman's disease
KW - Primary effusion lymphoma
UR - http://www.scopus.com/inward/record.url?scp=23844540421&partnerID=8YFLogxK
U2 - 10.1080/10408360590913524
DO - 10.1080/10408360590913524
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C2 - 15941082
AN - SCOPUS:23844540421
SN - 1040-8363
VL - 42
SP - 101
EP - 153
JO - Critical Reviews in Clinical Laboratory Sciences
JF - Critical Reviews in Clinical Laboratory Sciences
IS - 2
ER -