Kidney involvement and renal manifestations in non-Hodgkin's lymphoma and lymphocytic leukemia: A retrospective study in 700 patients

Nael Da'As, Aaron Polliack*, Yossi Cohen, Gail Amir, David Darmon, Yosef Kleinman, Ada W. Goldfarb, Dina Ben-Yehuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

202 Scopus citations

Abstract

Renal involvement as part of systemic lymphoma (LY) is quite frequent, however, primary extranodal renal non-Hodgkin's lymphoma (NHL) is extremely rare, and only about 65 cases have been reported in the world literature. In a retrospective study of renal manifestations in 700 patients with documented LY and chronic lymphocytic leukemia (CLL) seen at our hospital during 1986-95, 83 patients had signs of acute renal failure. Only five of these had proven renal infiltration, but none of them satisfied the criteria for primary renal LY. Glomerulonephritis (GN) has also rarely been reported in association with LY and CLL, and only 37 glomerular lesions in NHL and 42 in CLL have been documented, respectively. GN may precede, coexist, or follow the diagnosis of LY by several years. Of the 42 cases of CLL reported worldwide, 36 had nephrotic syndrome. Renal failure was seen in about one third. The most common glomerular lesion reported is membranoproliferative GN, followed by membranous GN. In our study, we found only five biopsy-proven cases with GN amongst the 700 patients seen. In this report we also briefly describe some rare interesting associated renal syndromes in CLL and NHL.

Original languageAmerican English
Pages (from-to)158-164
Number of pages7
JournalEuropean Journal of Haematology
Volume67
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Chronic lymphocytic leukemia (CLL)
  • Glomerulonephritis
  • Kidney involvement
  • Lymphoma
  • Non-Hodgkin's lymphoma
  • Renal failure

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