Kinetic instability of p53 core domain mutants. Implications for rescue by small molecules

Keyphrases

• Small Molecules 100%
• P53 Core Domain 100%
• Kinetic Instabilities 100%
• Wild-type p53 66%
• Sequence Specificity 33%
• Tumor Protein p53 (TP53) 33%
• Dimerization Domain 33%
• DNA Binding 33%
• High Concentration 33%
• Binding Protein 33%
• Mutant Protein 33%
• Target DNA 33%
• Body Temperature 33%
• Oncogenic mutations 33%
• Denatured Protein 33%
• Folded Conformation 33%
• Binding Core 33%
• Stabilized Peptide 33%
• Thermodynamic Instability 33%
• Unfolding Rate 33%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Small Molecule 100%
• Conformation 22%
• Wild Type 22%
• DNA Binding 11%
• Binding Protein 11%
• Anabolism 11%
• Carcinogenesis 11%
• Mutant Protein 11%
• Body Temperature 11%
• Denatured Protein 11%