Kinetic properties of glucosyltransferase adsorbed onto saliva-coated hydroxyapatite

Doron Steinberg*, Darcy Beeman, William H. Bowen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Results from previous studies have shown that several properties of glucosyltransferase (GTF) adsorbed onto saliva-coated hydroxyapatite (sHA) beads differ from those of GTF in solution, for example, in terms of thermostability, pH-activity dependency, and sensitivity to inhibitors. In this study, the kinetics of the adsorbed GTF is compared with that in solution. The results indicate that the rapid formation of glucans by GTF adsorbed onto sHA could have implications for colonization by oral microorganisms on tooth surfaces. The accelerated synthesis of glucan on tooth surfaces may affect the microbiology of the dental plaque, and might also influence the movement of substances, such as acids and antiplaque agents, across the acquired pellicle and dental plaque.

Original languageAmerican English
Pages (from-to)553-566
Number of pages14
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Issue number5
StatePublished - 1996
Externally publishedYes

Bibliographical note

Funding Information:
This investigation was supported in part by USPHS Research Grant DE07907 f r o m the National Institute of Dental Research, National Institute of Health, Bethesda, MD 20892, and the Fogarty Fellowship F05 TW04389.


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