Kinetics of catecholamine release by tyramine in rat heart, spleen and uterus

Y. Gutman; H. Weil-Malherbe

doi:10.1016/0024-3205(66)90030-0

Kinetics of catecholamine release by tyramine in rat heart, spleen and uterus

Y. Gutman^*, H. Weil-Malherbe

^*Corresponding author for this work

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Abstract

The kinetics of depletion of endogenous catecholamines by tyramine were studied in rat heart, spleen and uterus. 85-93% of the catecholamines of these organs can be depleted by repeated injections of tyramine over 3 1/2 hours. The depletion follows a simple exponential curve with "half-life" times for heart, spleen and uterus of 55, 69 and 75 minutes, respectively. The releasing effect of tyramine is not significantly affected by blockade of catecholamine uptake by phenoxybenzamine.

Original language	English
Pages (from-to)	1293-1298
Number of pages	6
Journal	Life Sciences
Volume	5
Issue number	14
DOIs	https://doi.org/10.1016/0024-3205(66)90030-0
State	Published - Jul 1966
Externally published	Yes

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abstract = "The kinetics of depletion of endogenous catecholamines by tyramine were studied in rat heart, spleen and uterus. 85-93% of the catecholamines of these organs can be depleted by repeated injections of tyramine over 3 1/2 hours. The depletion follows a simple exponential curve with {"}half-life{"} times for heart, spleen and uterus of 55, 69 and 75 minutes, respectively. The releasing effect of tyramine is not significantly affected by blockade of catecholamine uptake by phenoxybenzamine.",

author = "Y. Gutman and H. Weil-Malherbe",

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N2 - The kinetics of depletion of endogenous catecholamines by tyramine were studied in rat heart, spleen and uterus. 85-93% of the catecholamines of these organs can be depleted by repeated injections of tyramine over 3 1/2 hours. The depletion follows a simple exponential curve with "half-life" times for heart, spleen and uterus of 55, 69 and 75 minutes, respectively. The releasing effect of tyramine is not significantly affected by blockade of catecholamine uptake by phenoxybenzamine.

AB - The kinetics of depletion of endogenous catecholamines by tyramine were studied in rat heart, spleen and uterus. 85-93% of the catecholamines of these organs can be depleted by repeated injections of tyramine over 3 1/2 hours. The depletion follows a simple exponential curve with "half-life" times for heart, spleen and uterus of 55, 69 and 75 minutes, respectively. The releasing effect of tyramine is not significantly affected by blockade of catecholamine uptake by phenoxybenzamine.

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Kinetics of catecholamine release by tyramine in rat heart, spleen and uterus

Abstract

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