Abstract
The kinetics of depletion of endogenous catecholamines by tyramine were studied in rat heart, spleen and uterus. 85-93% of the catecholamines of these organs can be depleted by repeated injections of tyramine over 3 1/2 hours. The depletion follows a simple exponential curve with "half-life" times for heart, spleen and uterus of 55, 69 and 75 minutes, respectively. The releasing effect of tyramine is not significantly affected by blockade of catecholamine uptake by phenoxybenzamine.
| Original language | English |
|---|---|
| Pages (from-to) | 1293-1298 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 5 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 1966 |
| Externally published | Yes |