Koninginin b: A Biologically Active Congener of Koninginin a from Trichoderma Koningii

Horace G. Cutler; David S. Himmelsbach; John M. Jacyno; Patsy D. Cole; Boris Yagen; Richard F. Arrendale; Richard H. Cox

doi:10.1021/jf00005a035

Koninginin b: A Biologically Active Congener of Koninginin a from Trichoderma Koningii

Horace G. Cutler^*
, David S. Himmelsbach
, John M. Jacyno
, Patsy D. Cole
, Boris Yagen
, Richard F. Arrendale
, Richard H. Cox

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Koninginin B, a biologically active natural product related to koninginin A, was isolated from Tri-choderma koningii, an organism isolated from the roots and soil line of a Diffenbachia sp. The compound, which inhibited the growth of etiolated wheat coleoptiles 100 % at 10⁻³ M, was a white, finely crystalline compound with molecular formula C₁₆H₂₆O₄ and a melting point of 72-74 °C. The structure was established as 8-hydroxy-2-(l-hydroxyheptyl)-3,4,5,6,7,8-hexahydro-2H-1-benzopyran-5-one by comparison with koninginin A, UV, IR, ¹H NMR, ¹³C NMR, and MS.

Original language	English
Pages (from-to)	977-980
Number of pages	4
Journal	Journal of Agricultural and Food Chemistry
Volume	39
Issue number	5
DOIs	https://doi.org/10.1021/jf00005a035
State	Published - 1 May 1991

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title = "Koninginin b: A Biologically Active Congener of Koninginin a from Trichoderma Koningii",

abstract = "Koninginin B, a biologically active natural product related to koninginin A, was isolated from Tri-choderma koningii, an organism isolated from the roots and soil line of a Diffenbachia sp. The compound, which inhibited the growth of etiolated wheat coleoptiles 100 \% at 10−3 M, was a white, finely crystalline compound with molecular formula C16H26O4 and a melting point of 72-74 °C. The structure was established as 8-hydroxy-2-(l-hydroxyheptyl)-3,4,5,6,7,8-hexahydro-2H-1-benzopyran-5-one by comparison with koninginin A, UV, IR, 1H NMR, 13C NMR, and MS.",

author = "Cutler, \{Horace G.\} and Himmelsbach, \{David S.\} and Jacyno, \{John M.\} and Cole, \{Patsy D.\} and Boris Yagen and Arrendale, \{Richard F.\} and Cox, \{Richard H.\}",

year = "1991",

month = may,

day = "1",

doi = "10.1021/jf00005a035",

language = "אנגלית",

volume = "39",

pages = "977--980",

journal = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Koninginin b

T2 - A Biologically Active Congener of Koninginin a from Trichoderma Koningii

AU - Cutler, Horace G.

AU - Himmelsbach, David S.

AU - Jacyno, John M.

AU - Cole, Patsy D.

AU - Yagen, Boris

AU - Arrendale, Richard F.

AU - Cox, Richard H.

PY - 1991/5/1

Y1 - 1991/5/1

N2 - Koninginin B, a biologically active natural product related to koninginin A, was isolated from Tri-choderma koningii, an organism isolated from the roots and soil line of a Diffenbachia sp. The compound, which inhibited the growth of etiolated wheat coleoptiles 100 % at 10−3 M, was a white, finely crystalline compound with molecular formula C16H26O4 and a melting point of 72-74 °C. The structure was established as 8-hydroxy-2-(l-hydroxyheptyl)-3,4,5,6,7,8-hexahydro-2H-1-benzopyran-5-one by comparison with koninginin A, UV, IR, 1H NMR, 13C NMR, and MS.

AB - Koninginin B, a biologically active natural product related to koninginin A, was isolated from Tri-choderma koningii, an organism isolated from the roots and soil line of a Diffenbachia sp. The compound, which inhibited the growth of etiolated wheat coleoptiles 100 % at 10−3 M, was a white, finely crystalline compound with molecular formula C16H26O4 and a melting point of 72-74 °C. The structure was established as 8-hydroxy-2-(l-hydroxyheptyl)-3,4,5,6,7,8-hexahydro-2H-1-benzopyran-5-one by comparison with koninginin A, UV, IR, 1H NMR, 13C NMR, and MS.

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SN - 0021-8561

VL - 39

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JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 5

ER -

Koninginin b: A Biologically Active Congener of Koninginin a from Trichoderma Koningii

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